rat CCL2 (MCP-1)-InVivo [2H5]

Catalog No.A2132 Batch: A213205

Clone No.2H5

Anti-mouse/human/rat CCL2 (MCP-1)-InVivo (Clone: 2H5) antibody reacts with mouse, human, and rat CCL2, also known as monocyte chemoattractant protein 1 (MCP-1). MCP-1 is a 13 kDa chemokine produced mainly by monocytes/macrophages and is a potent monocyte-attracting chemokine. The 2H5 antibody has been shown to neutralize the biological effects of CCL2 in vivo.

Technical Data

Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Clone	2H5
Isotype	Armenian Hamster IgG, κ
Application	in vivo CCL2 neutralization, Immunohistochemistry (frozen)
Source	CHO
Murine Pathogen Screening Panel	all targets tested yielded Negative Results: Theiler’s Murine Encephalomyelitis Virus, Ectromelia (Mousepox) Virus, Hantavirus, Polyomavirus, Sendai Virus, Mycoplasma pulmonis, Pneumonia Virus of Mice, K Virus, Mouse Parvovirus, Mouse Hepatitis Virus, Mouse Norovirus, Mouse Minute Virus, Mouse Cytomegalovirus, Mouse Adenovirus, Lactate Dehydrogenase-Elevating Virus, Reovirus Panel, Lymphocytic Choriomeningitis Virus, Mouse Rotavirus.
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Sterility	6.64 mg/ml
Purity	99%
Protein concentration	6.64 mg/ml
Endotoxin Level	＜1EU/mg

Selleck's Anti-mouse/human/rat CCL2 (MCP-1)-InVivo [2H5] Has Been Cited by 10 publications

IL6/CCL2 from M2-polarized microglia promotes breast cancer brain metastasis and the reversal effect of β-elemene [ Frontiers in Pharmacology, May 15, 2025, 16:1547333]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40444044
Zhen-Wu-Tang ameliorates uremic cardiomyopathy via targeting the kidney–heart inflammatory axis and suppressing CCL2/CCR2-mediated macrophage activation [ Chinese Medicine, March 2026, 21:96]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41851781
Zhen-Wu-Tang ameliorates uremic cardiomyopathy via targeting the kidney-heart inflammatory axis and suppressing CCL2/CCR2-mediated macrophage activation [ Chinese Medicine, March 18, 2026, 21(1):96]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41851781
H3K18 lactylation drives CD8+ T cell exclusion and anti-PD-1 resistance in hepatocellular carcinoma [ Cell Reports, August 1, 2026, 45(8):117761]	https://www.ncbi.nlm.nih.gov/pubmed/?term=42519827
Preferential crosstalk between perifollicular capillary vessels and dermal papilla cells during hair cycling homeostasis [ Scientific Reports, April 1, 2026, 16(1):15328]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41922417
S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect [ Advanced Science, 2026-07, e22921]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41961478
Comprehensive genomic profiling of triple-negative breast cancer metastases identifies role of PKD1 in immunotherapy resistance [ J Clin Invest, 2026, 136(5)e188989]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41766665
USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment [ Cancer Immunol Res, 2025, 10.1158/2326-6066.CIR-24-1194]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40323348
USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment [ Cancer Immunology Research, 2025, 1226-1245]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40323348
IL6/CCL2 from M2-polarized microglia promotes breast cancer brain metastasis and the reversal effect of β-elemene [ Front Pharmacol, 2025, 16:1547333]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40444044

FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.

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