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Anti-mouse CD8α-InVivo
Catalog No.A2102 Batch: A210231
Clone No.2.43
Anti-mouse CD8α (Clone:2.43)reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC).
Technical Data
| Formulation | PBS buffer, pH 7.0 |
|---|---|
| Clone | 2.43 |
| Immunogen | Mouse CTL clone L3 |
| Isotype | Rat IgG2b, κ |
| Application | In vivo CD8+ T cell depletion,WB |
| Source | CHO |
| Murine Pathogen Screening Panel | all targets tested yielded Negative Results: Theiler’s Murine Encephalomyelitis Virus, Ectromelia (Mousepox) Virus, Hantavirus, Polyomavirus, Sendai Virus, Mycoplasma pulmonis, Pneumonia Virus of Mice, K Virus, Mouse Parvovirus, Mouse Hepatitis Virus, Mouse Norovirus, Mouse Minute Virus, Mouse Cytomegalovirus, Mouse Adenovirus, Lactate Dehydrogenase-Elevating Virus, Reovirus Panel, Lymphocytic Choriomeningitis Virus, Mouse Rotavirus. |
| Storage (From the date of receipt) |
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles |
| Sterility | 7.40 mg/ml |
| Purity | 99% |
| Protein concentration | 7.40 mg/ml |
| Endotoxin Level | ＜1EU/mg |
Customer Product Validation
Selleck's Anti-mouse CD8α-InVivo Has Been Cited by 100 publications
| Nuclear glycine decarboxylase suppresses STAT1-dependent MHC-I and promotes cancer immune evasion [ The EMBO Journal, September 8, 2025, 44(20):5712-5733] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=40926122 |
| Angiotensin receptor blocker attacks armored and cold tumors and boosts immune checkpoint blockade [ Journal for ImmunoTherapy of Cancer, September 6, 2024, e009327] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=39244215 |
| FLT3L combined with GM-CSF induced dendritic cells drive broad tumor-specific CD8+ T cell responses and remodel the tumor microenvironment to enhance anti-tumor efficacy [ Frontiers in Immunology, September 4, 2025, 16:1649891] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=40977690 |
| Spatiotemporal Analysis of Mesenchymal Stem Cells Fate Determination by Inflammatory Niche Following Soft Tissue Injury at a Single‐Cell Level [ Advanced Science, September 23, 2024, 11(43):2310282] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=39308190 |
| Radiation-induced upregulation of itaconate in macrophages promotes the radioresistance of non-small cell lung cancer by stabilizing NRF2 protein and suppressing immune response [ Redox Biology, September 1, 2025, 85:103711] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=40482348 |
| Urokinase-type plasminogen activator deficiency enhances CD8+ T cell infiltration and anti-PD-1 therapy efficacy in prostate cancer [ Frontiers in Immunology, September 1, 2025, 16:1625226] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=40959092 |
| Angiotensin receptor blocker attacks armored and cold tumors and boosts immune checkpoint blockade [ Journal for Immunotherapy of Cancer, September 1, 2024, 12(9):e009327] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=39244215 |
| Voluntary exercise sensitizes cancer immunotherapy via the collagen inhibition-orchestrated inflammatory tumor immune microenvironment [ Cell Reports, September 1, 2024, 43(9):114697] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=39217611 |
| Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice [ Frontiers in Immunology, October 9, 2023, 14:1272537] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=37901252 |
| LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation [ Cell Discovery, October 29, 2025, 11(1):84] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=41162356 |
FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.