Anti-mouse CD8α-InVivo

Catalog No.A2102 Batch: A210230

Clone No.2.43

Anti-mouse CD8α (Clone:2.43)reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC).

Technical Data

Formulation	PBS buffer, pH 7.0
Clone	2.43
Immunogen	Mouse CTL clone L3
Isotype	Rat IgG2b, κ
Application	In vivo CD8+ T cell depletion,WB
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Sterility	4.16 mg/ml
Purity	99%
Protein concentration	4.16 mg/ml
Endotoxin Level	＜1EU/mg

Customer Product Validation

Selleck's Anti-mouse CD8α-InVivo Has Been Cited by 42 publications

Senescent SPP1+ macrophages remodel the tumor microenvironment and promote the progression of early-stage lung adenocarcinoma featured with mixed ground glass nodule [ Mol Cancer, 2025, 24(1):298]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41310768
LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation [ Cell Discov, 2025, 11(1):84]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41162356
TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice [ Mil Med Res, 2025, 12(1):78]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41214839
Silencing PCSK9 reshapes the spatiotemporal activation of STING for safe and effective cancer immunotherapy [ Nat Commun, 2025, 10.1038/s41467-025-66630-x]	https://www.ncbi.nlm.nih.gov/pubmed/?term=41290746
Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity [ Nat Commun, 2025, 16(1):3546]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40229277
BET inhibitor in combination with BCG vaccine enhances antitumor efficacy and orchestrates T cell reprogramming for melanoma [ Cell Rep Med, 2025, 6(3):101995]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40107246
Nuclear glycine decarboxylase suppresses STAT1-dependent MHC-I and promotes cancer immune evasion [ EMBO J, 2025, 10.1038/s44318-025-00557-3]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40926122
Radiation-induced upregulation of itaconate in macrophages promotes the radioresistance of non-small cell lung cancer by stabilizing NRF2 protein and suppressing immune response [ Redox Biol, 2025, 85:103711]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40482348
Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway [ J Immunother Cancer, 2025, 13(2)e010252]	https://www.ncbi.nlm.nih.gov/pubmed/?term=39915005
Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer [ J Immunother Cancer, 2025, 13(7)e011948]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40664447

FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.