Anti-mouse CD8α-InVivo

Catalog No.A2102 Batch: A210225

Clone No.2.43

Anti-mouse CD8α (Clone:2.43)reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC).

Technical Data

Formulation	PBS buffer, pH 7.0
Clone	2.43
Immunogen	Mouse CTL clone L3
Isotype	Rat IgG2b, κ
Application	In vivo CD8+ T cell depletion,WB
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Sterility	6.60 mg/mL
Purity	99%
Protein concentration	6.60 mg/mL
Endotoxin Level	＜1 EU/mg

Customer Product Validation

Selleck's Anti-mouse CD8α-InVivo has been cited by 36 publications

Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity [ Nat Commun, 2025, 16(1):3546]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40229277
BET inhibitor in combination with BCG vaccine enhances antitumor efficacy and orchestrates T cell reprogramming for melanoma [ Cell Rep Med, 2025, 6(3):101995]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40107246
Nuclear glycine decarboxylase suppresses STAT1-dependent MHC-I and promotes cancer immune evasion [ EMBO J, 2025, 10.1038/s44318-025-00557-3]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40926122
Radiation-induced upregulation of itaconate in macrophages promotes the radioresistance of non-small cell lung cancer by stabilizing NRF2 protein and suppressing immune response [ Redox Biol, 2025, 85:103711]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40482348
Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway [ J Immunother Cancer, 2025, 13(2)e010252]	https://www.ncbi.nlm.nih.gov/pubmed/?term=39915005
Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer [ J Immunother Cancer, 2025, 13(7)e011948]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40664447
CD47 antibody-armed oncolytic adenovirus promotes chimeric antigen receptor macrophage phagocytosis and antitumor immunity [ Exp Hematol Oncol, 2025, 14(1):106]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40814015
Disulfiram/copper triggers cGAS-STING innate immunity pathway via ROS-induced DNA damage that potentiates antitumor response to PD-1 checkpoint blockade [ Int J Biol Sci, 2025, 21(4):1730-1748]	https://www.ncbi.nlm.nih.gov/pubmed/?term=39990655
Myeloid-lineage-specific membrane protein LRRC25 suppresses immunity in solid tumor and is a potential cancer immunotherapy checkpoint target [ Cell Rep, 2025, 44(5):115631]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40279244
Impact of gut microbiome on radiotherapy and immunotherapy efficacy in microsatellite-stable colorectal cancer: role of propionic acid and B. fragilis [ Br J Cancer, 2025, 10.1038/s41416-025-03105-2]	https://www.ncbi.nlm.nih.gov/pubmed/?term=40715695

FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.

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We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.