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Anti-mouse CD8α-InVivo
Catalog No.A2102 Batch: A210222
Clone No.2.43
Anti-mouse CD8α (Clone:2.43)reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC).
Technical Data
| Formulation | PBS buffer, pH 7.0 |
|---|---|
| Clone | 2.43 |
| Immunogen | Mouse CTL clone L3 |
| Isotype | Rat IgG2b, κ |
| Application | In vivo CD8+ T cell depletion,WB |
| Storage (From the date of receipt) |
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles |
| Sterility | 6.39 mg/mL |
| Purity | 99% |
| Protein concentration | 6.39 mg/mL |
| Endotoxin Level | ＜1EU/mg |
Customer Product Validation
Selleck's Anti-mouse CD8α-InVivo has been cited by 31 publications
| Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity [ Nat Commun, 2025, 16(1):3546] | PubMed: 40229277 |
| BET inhibitor in combination with BCG vaccine enhances antitumor efficacy and orchestrates T cell reprogramming for melanoma [ Cell Rep Med, 2025, 6(3):101995] | PubMed: 40107246 |
| Radiation-induced upregulation of itaconate in macrophages promotes the radioresistance of non-small cell lung cancer by stabilizing NRF2 protein and suppressing immune response [ Redox Biol, 2025, 85:103711] | PubMed: 40482348 |
| Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway [ J Immunother Cancer, 2025, 13(2)e010252] | PubMed: 39915005 |
| Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer [ J Immunother Cancer, 2025, 13(7)e011948] | PubMed: 40664447 |
| Disulfiram/copper triggers cGAS-STING innate immunity pathway via ROS-induced DNA damage that potentiates antitumor response to PD-1 checkpoint blockade [ Int J Biol Sci, 2025, 21(4):1730-1748] | PubMed: 39990655 |
| Myeloid-lineage-specific membrane protein LRRC25 suppresses immunity in solid tumor and is a potential cancer immunotherapy checkpoint target [ Cell Rep, 2025, 44(5):115631] | PubMed: 40279244 |
| Retinoic acid enhances γδ T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion [ Cell Commun Signal, 2025, 23(1):156] | PubMed: 40158172 |
| Tetrandrine augments melanoma cell immunogenicity via dual inhibition of autophagic flux and proteasomal activity enhancing MHC-I presentation [ Acta Pharmacol Sin, 2025, 10.1038/s41401-025-01507-9] | PubMed: 40016522 |
| TNFR2/CCR8 bispecific antibody enhances antitumor activity through depleting Ti-Tregs and boosting effector CD8+ T cell function [ Oncoimmunology, 2025, 14(1):2497171] | PubMed: 40293187 |
FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.