Anti-KDM6A/UTX Rabbit Antibody [J23B17]

Catalog No.: F4032

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Biological Description

Specificity Anti-KDM6A/UTX Rabbit Antibody [J23B17] recognizes total endogenous levels of KDM6A/UTX protein.
Background KDM6A (also known as UTX) is an X chromosome–encoded gene that produces a histone demethylase involved in chromatin remodeling and gene regulation. Its enzymatic activity specifically removes di- and tri-methyl groups from lysine 27 on histone H3 (H3K27me2/3), thereby relieving transcriptional repression, enhancing chromatin accessibility, and facilitating gene expression. In XX individuals, KDM6A consistently escapes X chromosome inactivation across various cell types and developmental stages in both humans and mice, leading to biallelic transcription and consequently higher expression in females. KDM6A plays a fundamental role in tissue- and cell-specific differentiation, as well as in embryonic development, homeotic gene regulation, and cellular reprogramming. Functionally, KDM6A interacts with members of the COMPASS complex, including the MLL3 and MLL4 lysine methyltransferases, to coordinate transcriptional programs. Importantly, mutations in KDM6A and its associated partners are recurrently found in a variety of human cancers, highlighting its significance as both a developmental regulator and a cancer-associated gene.

Usage Information

Application WB, FCM Dilution
WB FCM
1:1000 1:50
Reactivity Mouse, Human
Source Rabbit MW 154 kDa
Storage Buffer PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
Storage
(from the date of receipt)		 -20°C (avoid freeze-thaw cycles), 2 years

References

  • https://pubmed.ncbi.nlm.nih.gov/36268511/
  • https://pubmed.ncbi.nlm.nih.gov/30753822/

Application Data