Annexin-2/ANXA2 Rabbit mAb

Catalog No.: F4062

打印

Biological Description

Specificity Annexin-2/ANXA2 Rabbit mAb detects endogenous levels of total Annexin-2/ANXA2 protein.
Background Annexin-2/ANXA2 is a multifunctional, pleiotropic calcium- and anionic, phospholipid-binding protein of the annexin family that exists as a monomer or as a heterotetrameric complex (AIIt) with S100A10. Structurally, ANXA2 contains an N-terminal head domain, which undergoes post-translational modifications (acetylation, phosphorylation) and mediates interactions with S100A10, tissue plasminogen activator (tPA), and other proteins, and a conserved C-terminal core domain composed of four annexin repeats (~70 amino acids each) that bind Ca²⁺, phospholipids, heparin, RNA, and F-actin. ANXA2 is widely expressed in endothelial cells, monocytes/macrophages, neurons, and cancer cells, with expression upregulated by growth factors, oncogenes, hypoxia, and alternative splicing. Functionally, ANXA2 regulates diverse processes including exocytosis, endocytosis, membrane organization, actin cytoskeleton remodeling, redox balance, and cell surface plasmin generation (via stabilization and transport of S100A10). Its dysregulation is implicated in oncogenesis, fibrinolysis, inflammation, and neurodegenerative diseases, highlighting its pleiotropic roles in normal physiology and pathology.

Usage Information

Application WB, IHC, IF, FCM Dilution
WB IHC IF FCM
1:1000 - 1:20000 1:50 - 1:100 1:100 - 1:250 1:10 - 1:100
Reactivity Human
Source Rabbit MW 38 kDa
Storage Buffer PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
Storage
(from the date of receipt)		 -20°C (avoid freeze-thaw cycles), 2 years

References

  • https://pubmed.ncbi.nlm.nih.gov/23519104/
  • https://pubmed.ncbi.nlm.nih.gov/40141747/

Application Data