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Description
| Specificity | AhR Rabbit Recombinant mAb detects endogenous level of total AhR. |
|---|---|
| Background | The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that has proven to be an important regulator of cell physiology and organ homeostasis. At the cellular level, AhR establishes functional interactions with signaling pathways governing cell proliferation and cell cycle, cell morphology, cell adhesion and cell migration. At the molecular level, AhR regulates an increasingly large array of physiologically relevant genes either by traditional transcription-dependent mechanisms or by unforeseen processes involving genomic insulators, chromatin dynamics and the transcription of mobile genetic elements. AhR is also closely related to epigenetics. It influences the major stages of tumorigenesis--initiation, promotion, progression and metastasis--and physiologically relevant AHR ligands are often formed during disease states or during heightened innate and adaptive immune responses. |
Usage Information
| Application | WB,ELISA | ||
|---|---|---|---|
| Dilution |
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| Reactivity | Human | ||
| MW (kDa) | 105kDa | ||
| Source | Rabbit | ||
| Concentration | 1mg/ml | ||
| Storage buffer | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| Storage (From the date of receipt) |
Store at –20°C. |
References
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Application Data
WB