ADORA1 Rabbit Recombinant mAb Datasheet

Description

Specificity	ADORA1 Rabbit Recombinant mAb detects endogenous level of total ADORA1.
Background	The protective response to neuron damage is mainly due to endogenous adenosine. Adenosine P1 receptors are a class of purinergic and G protein-coupled receptors using adenosine as a ligand and consist of A1, A2a, A2b, and A3 subtypes. All adenosine receptors have been shown to activate at least one subfamily of mitogen-activated protein kinases. ADORA1 activation inhibits the release of presynaptic transmitters and stabilizes the postsynaptic membrane potential to reduce neuronal transmission and excitability. ADORA2A, another high affinity receptor, is thought to be preferentially activated by a high frequency stimulus, and then strengthen selected synaptic transmission within a globally inhibited network that could be formed by ADORA1 activation. ADORA1 is also an E2/ERα target and a regulator of ERα transcriptional activity.

Specificity

ADORA1 Rabbit Recombinant mAb detects endogenous level of total ADORA1.

Background

The protective response to neuron damage is mainly due to endogenous adenosine. Adenosine P1 receptors are a class of purinergic and G protein-coupled receptors using adenosine as a ligand and consist of A1, A2a, A2b, and A3 subtypes. All adenosine receptors have been shown to activate at least one subfamily of mitogen-activated protein kinases. ADORA1 activation inhibits the release of presynaptic transmitters and stabilizes the postsynaptic membrane potential to reduce neuronal transmission and excitability. ADORA2A, another high affinity receptor, is thought to be preferentially activated by a high frequency stimulus, and then strengthen selected synaptic transmission within a globally inhibited network that could be formed by ADORA1 activation. ADORA1 is also an E2/ERα target and a regulator of ERα transcriptional activity.

Usage Information

Application

WB, IHC,ELISA

Dilution

WB	IHC
1:1000	1:50

Reactivity

Human

MW (kDa)

37kDa

Source

Rabbit

Concentration

1mg/ml

Storage buffer

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

Storage
(From the date of receipt)

Store at –20°C.

References

Application Data

WB

Validated by Selleck

IHC