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Biological Description
| Specificity | ACTL6A/BAF53A Rabbit mAb detects endogenous levels of total ACTL6A/BAF53A protein. |
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| Background | ACTL6A (Actin-like protein 6A, also known as BAF53A) is a highly conserved actin-related protein and a core subunit of the SWI/SNF (BAF) chromatin remodeling complex, which regulates nucleosome positioning and transcriptional accessibility. Structurally, ACTL6A resembles actin in its ATP-binding fold but functions primarily in chromatin remodeling rather than cytoskeletal dynamics. It is predominantly expressed in stem cells, progenitor cells, neuronal precursors, and various epithelial tissues, where it maintains proliferative capacity and inhibits terminal differentiation. Functionally, ACTL6A promotes transcriptional programs associated with stemness, proliferation, epithelial–mesenchymal transition (EMT), and oncogenesis, often through interactions with transcription factors such as SOX2, c-Myc, p63, and signaling pathways including Notch and Hippo-YAP. Overexpression or amplification of ACTL6A has been reported in multiple cancers (e.g., hepatocellular carcinoma, ovarian cancer, head and neck squamous cell carcinoma, glioma, and cervical cancer), where it enhances tumor cell growth, invasion, therapy resistance, and poor prognosis, making it a critical oncogenic driver and potential therapeutic target. |
Usage Information
| Application | WB, IP, ChIP | Dilution |
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| Reactivity | Human, Monkey | ||||||||
| Source | Rabbit | MW | 45 kDa | ||||||
| Storage Buffer | PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3 | Storage (from the date of receipt) |
-20°C (avoid freeze-thaw cycles), 2 years | ||||||
References
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