Osthole

Catalog No.S2337 Batch:S233702

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Technical Data

Formula

C15H16O3
Molecular Weight 244.29 CAS No. 484-12-8
Solubility (25°C)* In vitro DMSO 49 mg/mL (200.58 mM)
Ethanol 49 mg/mL (200.58 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.
In vitro Osthol is an O-methylated coumarin which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. This compound inhibites platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. It mediates cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells and may be a promising agent for treating osteoporosis. This chemical also suppresses the secretion of hepatitis B virus in cell culture by increasing the glycosylation of HBsAg.
In vivo LD50: Rats >125mg/kg (i.v.); Rabbits >35mg/kg (i.v.); Dogs >150mg/kg (i.v.).

Protocol (from reference)

References

  • https://pubmed.ncbi.nlm.nih.gov/2556815/
  • https://pubmed.ncbi.nlm.nih.gov/15956019/
  • https://pubmed.ncbi.nlm.nih.gov/8781315/

Customer Product Validation

<p>(G) Kidney in situ ROS production demonstrated by DHE detection.</p>

, , Free Radic Biol Med, 2014, 73:260-9.

<p>Osthole attenuated liver injury and fibrogenesis in the TAA rat model. Representative liver sections were obtained from groups as follows: control, TAA and osthole-treated TAA rats. Liver sections were analyzed with a H&E-, b Picrosirius red- and c immunostaining of α-SMA.</p>

, , J Biomed Sci, 2015, 22:63.

Selleck's Osthole Has Been Cited by 19 Publications

蛇床子素对大鼠皮肤创面愈合和血管生成的影响及机制 (Effects and mechanism of osthole on skin wound healing and angiogenesis in rats) [ 中国药房 (China Pharmacy), 2025, 36(3): 324-329] PubMed: nan
Osthole induces accumulation of impaired autophagosome against pancreatic cancer cells [ Scientific Reports, 2024, 30163] PubMed: 39627455
Osthole induces accumulation of impaired autophagosome against pancreatic cancer cells [ Sci Rep, 2024, 14(1):30163] PubMed: 39627455
Osthole induces accumulation of impaired autophagosome against pancreatic cancer cells [ Scientific Reports, 2024, 30163] PubMed: 39627455.0
Osthole induces accumulation of impaired autophagosome against pancreatic cancer cells [ Scientific Reports, 2024, 14(1):30163] PubMed: 39627455
Osthole Inhibits M1 Macrophage Polarization and Attenuates Osteolysis in a Mouse Skull Model [ Oxid Med Cell Longev, 2023, 2023:2975193] PubMed: 36686380
Osthole Inhibits M1 Macrophage Polarization and Attenuates Osteolysis in a Mouse Skull Model [ Oxidative Medicine and Cellular Longevity, 2023, 2975193] PubMed: nan
Osthole Inhibits M1 Macrophage Polarization and Attenuates Osteolysis in a Mouse Skull Model [ Oxidative Medicine and Cellular Longevity, 2023, 2975193]
Coumarins of Lovage Roots (Levisticum officinale W.D.J.Koch): LC-MS Profile, Quantification, and Stability during Postharvest Storage [ Metabolites, 2022, 13(1)3] PubMed: 36676932
Coumarins of Lovage Roots (Levisticum officinale W.D.J.Koch): LC-MS Profile, Quantification, and Stability during Postharvest Storage [ Metabolites, 2022, 3] PubMed: 36676932.0

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.