Drospirenone

Catalog No.S1377 Batch:S137701

Technical Data

Formula

C₂₄H₃₀O₃

Molecular Weight

366.49

CAS No.

67392-87-4

Solubility (25°C)*

In vitro

DMSO

73 mg/mL (199.18 mM)

Ethanol

11 mg/mL (30.01 mM)

Water

Insoluble

In vivo (Add solvents to the product individually and in order)

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.65mg/ml (9.96mM)	Taking the 1 mL working solution as an example, add 50 μL of 73 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.52mg/ml (1.42mM)	Taking the 1 mL working solution as an example, add 50 μL of 10.4 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description

Drospirenone (ZK 3059) is a synthetic progestin that is an analog to spironolactone.

Targets

progestogen Receptor ^[1]

Protocol (from reference)

Selleck's Drospirenone Has Been Cited by 6 Publications

Impeding the combination of astrocytic ASCT2 and NLRP3 by talniflumate alleviates neuroinflammation in experimental models of Parkinsons disease [ Acta Pharmaceutica Sinica B, 2023, 662-677]	PubMed: 36873178
Impeding the combination of astrocytic ASCT2 and NLRP3 by talniflumate alleviates neuroinflammation in experimental models of Parkinson's disease [ Acta Pharm Sin B, 2023, 13(2):662-677]	PubMed: 36873178
Non-oncology drugs are a source of previously unappreciated anti-cancer activity [ Nature Cancer, 2020, 235-248]	PubMed: nan
Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling [ Nat Cancer, 2020, 1(2):235-248]	PubMed: 32613204
Drospirenone enhances GPIb-IX-V-mediated platelet activation [ Journal of Thrombosis and Haemostasis, 2015, 1918-1924]	PubMed: 26264726
Drospirenone enhances GPIb-IX-V-mediated platelet activation [ J Thromb Haemost, 2015, 13(10):1918-24]	PubMed: 26264726

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.