Calcifediol

Catalog No.S1469 Batch:S146902

Print

Technical Data

Formula

C27H44O2
Molecular Weight 400.64 CAS No. 19356-17-3
Solubility (25°C)* In vitro DMSO 80 mg/mL (199.68 mM)
Ethanol 20 mg/mL (49.92 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Calcifediol (Calcidiol, Didrogyl, Hidroferol, 25-hydroxyvitamin D3, 25-Hydroxycholecalciferol) is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It also suppresses PTH secretion and mRNA (ED50=2 nM).

Protocol (from reference)

Customer Product Validation

(E) Qualitative representations of zebrafish larvae, showing ISV to be unchanged or slightly reduced in response to 20 μM seocalcitol, maxacalcitol, calcitriol, calcifediol and tacalcitol treatment between 6 hpf and 2 dpf. Scale bar represents 200 μm. (F) Qualitative representation of intact ISV after 10 μM seocalcitol, maxacalcitol, calcitriol, calcifediol and tacalcitol treatment from 2-5 dpf. Scale bar represents 200 μm.

Data from [ , , Br J Pharmacol, 2017, 174(16):2636-2651 ]

Selleck's Calcifediol Has Been Cited by 18 Publications

Vitamin D supplementation is effective for olanzapine-induced dyslipidemia [ Front Pharmacol, 2023, 14:1135516] PubMed: 36895943
Vitamin D supplementation is effective for olanzapine-induced dyslipidemia [ Frontiers in Pharmacology, 2023, 1135516] PubMed: 36895943.0
Vitamin D3 suppresses the cholesterol homeostasis pathway in patient-derived glioma cell lines [ FEBS Open Bio, 2023, 1789-1806] PubMed: 37489660.0
Vitamin D3 suppresses the cholesterol homeostasis pathway in patient-derived glioma cell lines [ FEBS Open Bio, 2023, 13(9):1789-1806] PubMed: 37489660
FDA-Approved Drug Screening for Compounds That Facilitate Hematopoietic Stem and Progenitor Cells (HSPCs) Expansion in Zebrafish [ Cells, 2021, 10(8)2149] PubMed: 34440919
FDA-Approved Drug Screening for Compounds That Facilitate Hematopoietic Stem and Progenitor Cells (HSPCs) Expansion in Zebrafish [ Cells, 2021, 2149] PubMed: 34440919.0
Vitamin D Regulates MerTK-Dependent Phagocytosis in Human Myeloid Cells [ J Immunol, 2020, ji2000129] PubMed: 32540991
Vitamin D Regulates MerTK-Dependent Phagocytosis in Human Myeloid Cells [ The Journal of Immunology, 2020, 2694-2706] PubMed: 32540991.0
Vitamin D3 modulates yellow catfish (Pelteobagrus fulvidraco) immune function in vivo and in vitro and this involves the vitamin D3/VDR-type I interferon axis [ Developmental & Comparative Immunology, 2020, 103644] PubMed: 32061641.0
Vitamin D 3 Modulates Yellow Catfish (Pelteobagrus Fulvidraco) Immune Function in Vivo and in Vitro and This Involves the Vitamin D 3/VDR-type I Interferon Axis [ Dev Comp Immunol, 2020, 107:103644] PubMed: 32061641

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.