Andrographolide

Catalog No.S2261 Batch:S226103

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Technical Data

Formula

C20H30O5
Molecular Weight 350.45 CAS No. 5508-58-7
Solubility (25°C)* In vitro DMSO 70 mg/mL (199.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.
Targets
NF-κB [1]

Protocol (from reference)

References

  • https://pubmed.ncbi.nlm.nih.gov/15356172/

Selleck's Andrographolide Has Been Cited by 20 Publications

Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3 [ Proceedings of the National Academy of Sciences, October 01, 2018, E9869-E9878] PubMed: 30275324
Andrographolide Inhibits ER-Positive Breast Cancer Growth and Enhances Fulvestrant Efficacy via ROS-FOXM1-ER-α Axis [ Frontiers in Oncology, May 09, 2022, 899402] PubMed: 35615146
Andrographolide induces apoptosis in human osteosarcoma cells via the ROS/JNK pathway [ International Journal of Oncology, March 30, 2020, 1417-1428]
Targeting thioredoxin reductase 1 by Andrographolide contributes to inducing ROS-mediated apoptosis in human NSCLC cells [ Chem Biol Interact, 2025, 421:111778] PubMed: 41077336
Gastrodin mitigates aortic valve calcification by inhibiting glycolysis and histone lactylation through interfering with valve interstitial cells [ Frontiers in Pharmacology, 2025, 1547716] PubMed: 40556754
Andrographolide inhibits the proliferation and migration of vascular smooth muscle cells via PI3K/AKT signaling pathway and amino acid metabolism to prevent intimal hyperplasia [ European Journal of Pharmacology, 2023, 176082] PubMed: 37783303
Andrographolide Inhibits ER-Positive Breast Cancer Growth and Enhances Fulvestrant Efficacy via ROS-FOXM1-ER-α Axis [ Frontiers in Oncology, 2022, 899402] PubMed: 35615146
Andrographolide Inhibits Corneal Fibroblast to Myofibroblast Differentiation In Vitro [ Biomolecules, 2022, 12(10)1447] PubMed: 36291655
Andrographolide Inhibits Corneal Fibroblast to Myofibroblast DifferentiationIn Vitro [ Biomolecules, 2022, 12(10), 1447] PubMed: None
Andrographolide Inhibits Corneal Fibroblast to Myofibroblast Differentiation In Vitro [ Biomolecules, 2022, 12-101447] PubMed: 36291655

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.