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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C30H29F3N6O |
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| Molecular Weight | 546.59 | CAS No. | 1429617-90-2 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (182.95 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | 7rh (DDR1-IN-2) is a potent inhibitor of discoidin domain receptor 1 (DDR1) with an IC50 of 13.1 nM. It also inhibits DDR2 less effectively with an IC50 of 203 nM. It also exhibits antitumor effects in nasopharyngeal carcinoma cells. |
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Protocol (from reference)
References
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Selleck's 7rh Has Been Cited by 1 Publication
| Targeting Discoidin Domain Receptor 1 (DDR1) Signaling and Its Crosstalk with β1-Integrin Emerges as a Key Factor for Breast Cancer Chemosensitization upon Collagen Type 1 Binding [ International Journal of Molecular Sciences, 2020, 4956] | PubMed: 32668815 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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