7-Methylcoumarin

Catalog No.E0656 Batch:E065601

Print

Technical Data

Formula

C10H8O2
Molecular Weight 160.17 CAS No. 2445-83-2
Solubility (25°C)* In vitro DMSO 32 mg/mL (199.78 mM)
Ethanol 32 mg/mL (199.78 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description 7-Methylcoumarin can inhibit the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8–3.6 μg/ml, and also has a strong hepatoprotective activity.
In vitro

7-methylcoumarin is equipotent in inhibiting the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8-3.6 μg/ml, displaying no effects against Gram-negative bacteria and fungi.[1]
In vivo

Pretreatment with MC significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST) and serum bilirubin (TB) in the serum of CCl(4)-induced liver damaged rats in a dose-dependent manner, also prevents oxidative stress induced by CCl(4), thereby, increasing superoxide dismutase (SOD) and catalase (CAT) levels and decreasing thiobarbituric-acid-related substances (TBARS) levels in liver homogenates.[2]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    S. aureus, Gram-positive bacteria, Gram-negative bacteria, fungi

  • Concentrations

    --

  • Incubation Time

    --

  • Method

    --
Animal Study:

[2]
  • Animal Models

    Specific pathogen-free healthy male Sprague-Dawley rats

  • Dosages

    50, 100 mg/kg

  • Administration

    o.g.

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.