4-Hydroxychalcone

Catalog No.S4763 Batch:S476301

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Technical Data

Formula

C15H12O2

Molecular Weight 224.25 CAS No. 20426-12-4
Solubility (25°C)* In vitro DMSO 44 mg/mL (196.2 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description 4-Hydroxychalcone (P-Cinnamoylphenol) is a chalcone metabolite with diverse biological activities. It inhibits TNFα-induced NF-κB pathway activation in a dose-dependent manner and also activates BMP signaling.
Targets
NF-κB [1]
In vivo 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice[1].

Protocol (from reference)

Animal Study:[1]
  • Animal Models

    cryptochrome-null mice

  • Dosages

    10 mg/kg, 20 mg/kg and 40 mg/kg

  • Administration

    oral administration

Selleck's 4-Hydroxychalcone has been cited by 1 publication

Chemopreventive effect of 4'-hydroxychalcone on intestinal tumorigenesis in ApcMin mice [ Oncol Lett, 2021, 21(3):213] PubMed: 33510814

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.