4-Chloro-DL-phenylalanine

Catalog No.S4586 Batch:S458601

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Technical Data

Formula

C9H10ClNO2

Molecular Weight 199.63 CAS No. 7424-00-2
Solubility (25°C)* In vitro Water 3.75 mg/mL (18.78 mM)
DMSO 2 mg/mL (10.01 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description 4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.
Targets
tryptophan hydroxylase [1]
In vivo 4-Chloro-DL-phenylalanine(PCPA) markedly attenuates MCT(monocrotaline)-induced pulmonary vascular remodeling and lung inflammation, inhibits the expression of Tph-1 and SERT and suppresses the expression of MMP-2/-9, TIMP-1/-2, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1). PCPA inhibits 5-HT by suppressing Tph-1, regulating SERT and the serotonin downstream signaling pathway[1].

Protocol (from reference)

Animal Study:

[1]

  • Animal Models

    Sprague-Dawley (SD) rats 

  • Dosages

    50 or 100 mg/kg/day

  • Administration

    i.p.

Selleck's 4-Chloro-DL-phenylalanine has been cited by 3 publications

Sustained AhR activity programs memory fate of early effector CD8+ T cells [ Proc Natl Acad Sci U S A, 2024, 121(11):e2317658121] PubMed: 38437537
Regular Aerobic Exercise Attenuates Pain and Anxiety in Mice by Restoring Serotonin-Modulated Synaptic Plasticity in the Anterior Cingulate Cortex [ Med Sci Sports Exerc, 2022, 54(4):566-581] PubMed: 34935710
Increasing serotonin concentrations alter calcium metabolism in periparturient dairy goats [ J Anim Sci, 2022, skac065] PubMed: 35235945

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.