3-Hydroxybutyric acid (BHB)

Catalog No.S1031 Batch:S103101

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Technical Data

Formula

C4H8O3

 
Molecular Weight 104.10 CAS No. 300-85-6
Solubility (25°C)* In vitro  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description 3-Hydroxybutyric acid (BHB) is a small molecule metabolite that is elevated in type I diabetes.,
In vitro

3-Hydroxybutyric acid (BHB) suppresses activation of the NLRP3 inflammasome in response to several structurally unrelated NLRP3 activators, without impacting NLRC4, AIM2 or non-canonical caspase-11 inflammasome activation. 3-Hydroxybutyric acid reduces the NLRP3 inflammasome mediated IL-1β and IL-18 production in human monocytes.[1]
In vivo

Exogenous 3‐HB effectively delayed tumor growth in A549 xenograft mice.
Density 1.126 g/mL at 25 °C

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    Mouse bone marrow derived macrophages (BMDMs)

  • Concentrations

    10 mM

  • Incubation Time

    1 h

  • Method

    BMDMs are primed with LPS for 4 hours and stimulated with ATP for 1 hour in the presence of various concentrations of 3-Hydroxybutyric acid. Western blot analyses caspase-1 (active subunit p20) and IL-1β (active p17) in the supernatant of BMDMs

Selleck's 3-Hydroxybutyric acid (BHB) has been cited by 1 publication

Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway [ BMC Med, 2022, 20(1):148] PubMed: 35422042

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.