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Technical Data
| Formula | C7H5ClO3 |
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| Molecular Weight | 172.57 | CAS No. | 53984-36-4 | |
| Solubility (25°C)* | In vitro | DMSO | 34 mg/mL (197.02 mM) | |
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | 3-chloro-5-hydroxybenzoic Acid is a selective agonist of the lactate receptor GPR81. |
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| In vitro | 3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM).[1] |
| In vivo | 3-Chloro-5-hydroxybenzoic acid (30 mg/kg, 100 mg/kg, 300 mg/kg) shows significant reductions in free fatty acids, resulting in a minimum efficacious dose of 30 mg/kg.[1] |
Protocol (from reference)
Selleck's 3-chloro-5-hydroxybenzoic Acid has been cited by 3 publications
| Macrophages facilitate tumor cell PD-L1 expression via an IL-1β-centered loop to attenuate immune checkpoint blockade [ MedComm (2020), 2023, 4(2):e242] | PubMed: 37009412 |
| Macrophages facilitate tumor cell PD-L1 expression via an IL-1β-centered loop to attenuate immune checkpoint blockade [ MedComm (2020), 2023, 4(2):e242] | PubMed: 37009412 |
| Lactate Mediates High-Intensity Interval Training-Induced Promotion of Hippocampal Mitochondrial Function through the GPR81-ERK1/2 Pathway [ Antioxidants (Basel), 2023, 12(12)2087] | PubMed: 38136207 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.