COMPOUND LIBRARY AND ITS BENIFITS

THE BASIC CONCEPT OF COMPOUND LIBRARY:
The collection of data about different compounds at a place where all these compounds can be analyzed by the good worth of their storage is known as a compound library. Hence compound library is basically a collection or arrangement of different compounds. The maintenance, storage and placing of these screening compounds is actually a proper scientific way. The development of different new and emerging technologies in designing and managing of a chemical screening library has brought very remarkable success and changes in the procedure of drug discovery and these new changes have a great and positive impact on the ongoing research on drug discovery [1]. The most determining and crucial step in this procedure of compound library screening is the selection of biologically relevant and useful compounds and molecules that is usually guided by some experts of this area who would must devise some detailed protocols and schemes to make this process of selection faster, more efficient and better than ever in generating a resourceful research chemicals library. State-of-the-art methodologies that include both the fragment-based library designing and the structure-based small molecule library designing procedure is supported by the latest and efficient software tools which ensure a promising implementation of a small molecule drug screening library.
 

HOW TO SCHEME COMPOUND LIBRARIES:
As describes earlier, though the maintenance and design a compound screen library is an extraordinary task, a meticulous description of chemical molecules and regarding implementation advices by the experts has made this critical step much easier in getting promising and optimal results. The emerging technologies are very helpful in searching the new and vital drugs and chemicals against different diseases. A bioactive small molecule library is very reasonably supported by a rich and systematic database containing all the most relevant knowledge about the constituents of this chemical catalog. This knowledge usually contains purity of the preparation of compounds, their chemical structures and their all chemical, physical and the pharmacological properties [2].
 

SCREENING OF A COMPOUND LIBRARY:
The most important utility and advantage of a compound chemical library screening is its facilitation of a thorough and efficient screening in the assay of high throughput screening. A complete chemical screening helps greatly in developing a drug against a particular disease. Often a big molecule library is sub divided into some smaller sets of compound libraries. This classification depends upon the pharmacological and structural properties of chemicals and its purpose is usually to shorten the screening procedure. The reality behind this thought is that a kind of phosphatases or kinases would must be grouped together hence would be the different chemical compounds but derived from same parent molecule. So in order to screening of a drug, rather than screening a whole library, smaller sub sets are usually screened and there are higher chances of finding a hit compound which will save much reagents, time and efforts. The procedure of chemical screening is still elaborate though- even a single hit is always further re-screened for the confirmation of the activity of the drug against the particular or desired condition [3]. The detailed information of only that particular compound is included in the catalog which was further gone for the preclinical trials including different in vivo and in vitro trials before further suggesting it for the clinical studies [4]. Different advances in technologies and different software in the area of science have made the procedure of small molecular inhibitors screening much more promising by making the way of designing more systematic [5]. 
 

REFERENCES:
1. Zhou, J., Chemical Library Design. Methods in Molecular Biology. Vol. 685. 2011: Humana Press.
2. Schneider P, e.a., Self-Organizing Maps in Drug Discovery: Compound Library Design, Scaffold-Hopping, Repurposing Current Medicinal Chemistry, 2009.
3. Su GH, e.a., A Novel Histone Deacetylase Inhibitor Identified by High-Throughput Transcriptional Screening of a Compound Library. Cancer Res, 2000.
4. Huggins DJ, e.a., Rational Methods for the Selection of Diverse Screening Compounds. ACS Chem. Biol., 2011.
5. Gaillard Y, e.a., Use of high-performance liquid chromatography with photodiode-array UV detection for the creation of a 600-compound library application to forensic toxicology. Journal of Chromatography A, 1997.