TRPV

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2773 SB705498 <1 mg/mL 86 mg/mL 20 mg/mL
S4022 Probenecid <1 mg/mL 57 mg/mL 22 mg/mL
S7115 AMG-517 <1 mg/mL 86 mg/mL <1 mg/mL
S8137 Capsazepine <1 mg/mL 75 mg/mL 75 mg/mL
S8367 GSK2193874 <1 mg/mL 100 mg/mL 50 mg/mL
S3605 Borneol <1 mg/mL 30 mg/mL 30 mg/mL
S8107 GSK1016790A <1 mg/mL 100 mg/mL 100 mg/mL
S8238 SB366791 <1 mg/mL 57 mg/mL <1 mg/mL
S4516 (+)-Camphor <1 mg/mL 30 mg/mL 30 mg/mL
Catalog No. Information Product Use Citations Product Validations
S2773

SB705498

SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.

S4022

Probenecid

Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16.

S7115

AMG-517

AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM, respectively.

S8137New

Capsazepine

Capsazepine acts as a competitive antagonist of capsaicin and a transient receptor potential vanilloid type 1(TRPV1) antagonist.

S8367New

GSK2193874

GSK2193874 is an orally active, potent, and selective blocker of transient receptor potential vanilloid 4 (TRPV4) with IC50 values of 0.04 and 0.002 μM for hTRPV4 and rTRPV4, respectively.

S3605New

Borneol

Borneol is a bicyclic monoterpenoid compound extracted from medicinal plants such as Blumea balsamifera, and Dryobalanops aromatica. It is a TRPM8 agonist that increases ocular surface wetness.

S8107

GSK1016790A

GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.

S8238

SB366791

SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist.

S4516

(+)-Camphor

Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3.