TRPV

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2773 SB705498 <1 mg/mL 86 mg/mL 20 mg/mL
S4022 Probenecid <1 mg/mL 57 mg/mL 22 mg/mL
S7115 AMG-517 <1 mg/mL 86 mg/mL <1 mg/mL
S8137 Capsazepine <1 mg/mL 75 mg/mL 75 mg/mL
S8367 GSK2193874 <1 mg/mL 100 mg/mL 50 mg/mL
S8107 GSK1016790A <1 mg/mL 100 mg/mL 100 mg/mL
S8238 SB366791 <1 mg/mL 57 mg/mL <1 mg/mL
S4516 (+)-Camphor <1 mg/mL 30 mg/mL 30 mg/mL
Catalog No. Information Product Use Citations Product Validations
S4022

Probenecid

Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16.

S8367New

GSK2193874

GSK2193874 is an orally active, potent, and selective blocker of transient receptor potential vanilloid 4 (TRPV4) with IC50 values of 0.04 and 0.002 μM for hTRPV4 and rTRPV4, respectively.

S8107

GSK1016790A

GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.

S4516

(+)-Camphor

Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3.

S2773

SB705498

SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.

S7115

AMG-517

AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM, respectively.

S8137New

Capsazepine

Capsazepine acts as a competitive antagonist of capsaicin and a transient receptor potential vanilloid type 1(TRPV1) antagonist.

S8238

SB366791

SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist.

Catalog No. Information Product Use Citations Product Validations
S4022

Probenecid

Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16.

S8367New

GSK2193874

GSK2193874 is an orally active, potent, and selective blocker of transient receptor potential vanilloid 4 (TRPV4) with IC50 values of 0.04 and 0.002 μM for hTRPV4 and rTRPV4, respectively.

Catalog No. Information Product Use Citations Product Validations
S8107

GSK1016790A

GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.

S4516

(+)-Camphor

Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3.

Catalog No. Information Product Use Citations Product Validations
S2773

SB705498

SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.

2014, 10.1016/j.bbamcr.2014.07.005

S7115

AMG-517

AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM, respectively.

S8137New

Capsazepine

Capsazepine acts as a competitive antagonist of capsaicin and a transient receptor potential vanilloid type 1(TRPV1) antagonist.

S8238

SB366791

SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist.