γ-Secretase Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2714 LY411575

LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with IC50 of 0.39 nM.

Pan γ secretase (cell-based), IC50: 0.082 nM; γ secretase (membrane-based), IC50: 0.078 nM
S2711 YO-01027 (Dibenzazepine)

YO-01027 (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively.

Pan γ secretase(APPL), IC50: 2.6 nM
S1575 RO4929097

RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.

Pan γ secretase, IC50: 4 nM