TrkA Selective Inhibitors
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2.
|Selective||TrkA, IC50: 2 nM|
BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.
|Pan||TrkA, IC50: 7.4 nM|
GNF-5837 is a selective, and orally bioavailable pan-TRK inhibitor for TrkA, and TrkB with IC50 of 8 nM, and 12 nM, respectively.
|Pan||TrkA, IC50: 11 nM|