A1 Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1001 ABT-263 (Navitoclax)

ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM, but binds more weakly to Mcl-1 and A1. Phase 2.

Pan A1, Ki: 354 nM