The CMGC (including cyclin-dependent kinases (CDKs), mitogen-activated protein kinases (MAP kinases), glycogen synthase kinases (GSK) and CDK-like kinases) are an essential and typically large group of kinases found in all eukaryotes. CDKs regulate the progression through the different phases of the cell cycle in association with their activating partners cyclins. Tumour progression is frequently associated with genetic or epigenetic alterations in CDKs (or cyclins), which help sustain proliferation with independence from external mitogenic or antimitogenic signals.

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