The apoptosis-related genes include both cytoplasmic and membrane bound proteins implicated in programmed cell death, including caspase, Bcl-2, and tumor necrosis factor (TNF) families. Apoptosis, or programmed cell death, is needed for proper tissue development and as a defense against cells that represent a threat to the organism. It serves as an essential counterbalance to cellular proliferation. Dysfunction in the apoptotic pathway can result in cancer, autoimmune diseases, and increased spreading of viral infection.

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