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Cardiovascular Disease

Cat.No.	Product Name	Added

S2199	Aliskiren hemifumarate	Feb 2011
Aliskiren hemifumarate is a hemifumarate salt form of Aliskiren. Aliskiren is a novel orally effective direct renin inhibitor with an IC50 of 0.72 nM against renin.

S2560	Amilorida	Sep 2011
Amilorida is a potent epithelial sodium channel blocker.

S1671	Aminocaproic acid(Amicar)	Nov 2010
Aminocaproic acid(Amicar) is a derivative and analogue of the amino acid lysine.

S1813	Amlodipine besylate (Norvasc)	Dec 2010
Amlodipine besylate (Norvasc), a long-acting dihydropyridine calcium channel blocker, is effective in the treatment of angina pectoris and hypertension

S1905	Amlodipine(Norvasc)	Jan 2011
Amlodipine(Norvasc) is a long-acting calcium channel blocker with an IC50 of 1.9 nM.

S1593	Apixaban	Nov 2010
Apixaban is a direct factor Xa inhibitor with an IC50 of 0.22±0.02 µM.

S1284	Benazepril	Jun 2010
Benazepril is a medication used to treat high blood pressure.

S2017	Benidipine hydrochloride	Jan 2012
Benidipine hydrochloride is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.

S1827	Betaxolol hydrochloride (Betoptic)	Jan 2012


S2196	BIBR 953(Dabigatran)	Jan 2011
BIBR 953(Dabigatran) is a reversible, competitive, direct thrombin inhibitor.

S2154	BIBR-1048 (Dabigatran etexilate)	Dec 2010
BIBR-1048 (Dabigatran etexilate) is an anticoagulant from the class of the direct thrombin inhibitors.

S1407	Bimatoprost	Jul 2010
Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

S1206	Bisoprolol	May 2010
Bisoprolol is a selective type β1 adrenergic receptor blocker.

S1571	BMS-740808	Nov 2010
BMS-740808 is a highly potent, selective, efficacious, and orally bioavailable blood coagulation factor Xa inhibitor with a Ki of 30 pM.

S1287	Bumetanide	Jun 2010
Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure.

S1578	Candesartan (Atacand)	Nov 2010
Candesartan (Atacand) is an angiotensin II receptor antagonist with an IC50 of 15 µg/kg.

S2037	Candesartan cilexetil(Atacand)	Mar 2011
Candesartan cilexetil (Atacand) is a specific nonpeptide Ang II receptor (ATR) antagonist and the prodrug of candesartan which is an ATR antagonist with an IC50 of 15 µg/kg.

S1831	Carvedilol	Sep 2011
Carvedilol is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation.

S2280	Chlorogenic acid	Jan 2011
Chlorogenic acid is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.

S1641	Chlorothiazide(Diuril, Chlotride)	Oct 2010
Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM)

S2456	Chlorpromazine (Sonazine)	Jan 2011
Chlorpromazine (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 µM for nward-rectifying K+ currents and time-independent outward currents.

S1294	Cilostazol	Jun 2010
Cilostazol is a medication used in the alleviation of the symptom of intermittent claudication in individuals with peripheral vascular disease.

S2665	Ciprofibrate	Sep 2011
Ciprofibrate is a peroxisome proliferator-activated receptor agonist.

S2664	Clinofibrate	Sep 2011
Clinofibrate is a new hypelipidemic agent and a competitive hydroxymethylglutaryl coenzyme A reductase with an IC50 of 0.47 mM.

S2458	Clonidine hydrochloride(Catapres)	Jan 2011
Clonidine hydrochloride(Catapres) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.

S1415	Clopidogrel (Plavix)	Jul 2010
Clopidogrel (Plavix) is an oral, thienopyridine class antiplatelet agent.

S2402	Cyclovirobuxin D(Bebuxine)	Mar 2011
Cyclovirobuxine D (bebuxine; Cyclovirobuxine) is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia.

S2381	D-Mannitol(Osmitrol)	Feb 2011
D-Mannitol(Osmitrol) is an osmotic diuretic agent and a weak renal vasodilator.

S1712	Deferasirox(Exjade)	Jan 2011
Deferasirox(Exjade) is a rationally-designed oral iron chelator.

S1222	Dexrazoxane Hydrochloride	May 2010
Dexrazoxane hydrochloride is a cardioprotective agent.

S1865	Diltiazem HCl (Tiazac)	Dec 2010
Diltiazem HCl(Tiazac) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.

S2292	Diosmin	Jan 2011
Diosmin is a semisynthetic phlebotropic agent and a member of the flavonoid family.

S1895	Dipyridamole (Persantine)	Dec 2010
Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.

S2293	DL-Carnitine hydrochloride	Jan 2011
DL-Carnitine hydrochloride is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine.

S1658	Dofetilide(Tikosyn)	Jan 2011
Dofetilide(Tikosyn) is a class III antiarrhythmic agent.

S1324	Doxazosin	Jun 2010
Doxazosin is an alpha-1 adrenergic receptor blocker.

S1326	Edaravone (MCI-186)	Jun 2010
Edaravone(MCI-186), a strong novel free radical scavenger, is used for treatment of patients with acute brain infarction.

S1941	Enalapril maleate (Vasotec)	Dec 2010
Enalapril maleate (Vasotec), the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II.

S1657	Enalaprilat	Dec 2010
Enalaprilat is the first dicarboxylate-containing ACE inhibitor with an IC50 of 4 nM.

S2521	Epinephrine bitartrate (Adrenalinium)	Apr 2011
Epinephrine bitartrate (D02149, Adrenalinium) is alpha- and beta-adrenergic receptor stimulator.

S1707	Eplerenone	Dec 2010
Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM.

S1743	Esomeprazole magnesium(Nexium)	Jan 2011
Esomeprazole magnesium(Nexium) is a proton pump inhibitor to reduce gastric acid secretion.

S1885	Felodipine (Plendil)	Dec 2010
Felodipine (Renedil) is a calcium channel blocker with IC50 of 3 and 2 µM for the formyl-Met-Leu-Phe-induced cytosolic calcium increase and H2O2 production, respectively.

S2030	Flunarizine dihydrochloride	Jan 2012


S2299	Formononetin(Formononetol)	Jan 2011
Formononetin(Formononetol) is a phytoestrogen from the root of Astragalus membranaceus and an O-methylated isoflavone.

S2020	Formoterol hemifumarate	Jan 2012
Formoterol hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist to β2 and β1 receptors with pKd of 8.12 and 5.58, respectively.

S1603	Furosemide(Lasix)	Sep 2010
Furosemide(Lasix) is a loop diuretic used in the treatment of congestive heart failure and edema.

S2383	Gastrodin(Gastrodine)	Feb 2011
Gastrodin(Gastrodine) is a polyphenol. It is the glucoside of 4-hydroxybenzyl alcohol (gastrodigenin).

S2630	GW3965	Jul 2011
GW3965 is a synthetic selective, active non-steroidal liver X receptor (LXR) agonist with EC50 of 0.19 and 0.03 μM for hLXRα and hLXRβ, respectively.

S2723	Heparin sodium 110 U/mg	Nov 2011
Heparin sodium 110 U/mg is a sodium salt of heparin which is a naturally-occurring anticoagulant used for anticoagulation for cardiovascular disease.

S1346	Heparin sodium 150 U/mg	Jun 2010
Heparin sodium 150 U/mg is a sodium salt of heparin which is a naturally-occurring anticoagulant used for anticoagulation for cardiovascular disease.

S2724	Heparin sodium 180 U/mg	Nov 2011
Heparin sodium 180 U/mg is a sodium salt of heparin which is a naturally-occurring anticoagulant used for anticoagulation for cardiovascular disease.

S2308	Hesperetin	Jan 2011
Hesperetin is a bioflavonoid and, to be more specific, a flavanone.

S2309	Hesperidin	Jan 2011
Hesperidin is a flavanone glycoside found abundantly in citrus fruits.

S2562	Hydralazine hydrochloride	May 2011
Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM.

S1730	Indapamide(Lozol)	Dec 2010
Indapamide(Lozol, Arifon, Fludex, Noranat, Veroxil, Tertensif) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.

S1507	Irbesartan (Avapro)	Sep 2010
Irbesartan (Avapro) belongs to the class of medicines called angiotensin II inhibitor antihypertensives.

S2566	Isoprenaline hydrochloride	May 2011
Isoprenaline hydrochloride is a beta-adrenergic agonist.

S1662	Isradipine(Dynacirc)	Jan 2011
Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.

S2232	Ketanserin	Apr 2011
Ketanserin is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A.

S1994	Lacidipine (Lacipil, Motens)	Jan 2012
Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker.

S1359	Losartan potassium	Jun 2010
Losartan is an angiotensin II receptor antagonist drug.

S2481	Manidipine (Manyper)	Jan 2011
Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM.

S2482	Manidipine HCl (CV-4093)	Jan 2011
Manidipine HCl (CV-4093) is a hydrochloride salt of manidipine that is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM.

S2323	Methyl-Hesperidin	Jan 2011
Methyl-Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin.

S1610	Metolazone(Zaroxolyn)	Sep 2010
Metolazone(Zaroxolyn) is primarily used to treat congestive heart failure and high blood pressure.

S2484	Milrinone(Primacor)	Jan 2011
Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 µM for the inhibition of FIII PDE.

S1386	Nafamostat mesylate	Jul 2010
Nafamostat is an anticoagulant.

S1387	Naftopidil Dihydrochloride	Jul 2010
Naftopidil Dihydrochloride is an antihypertensive agent.

S2126	Naftopidil(Flivas)	Jan 2011
Naftopidil (Flivas) is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM.

S2519	Naphazoline hydrochloride (Naphcon)	Apr 2011
Naphazoline hydrochloride (Naphcon) is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.

S2329	Naringin (Naringoside)	Jan 2011
Naringin (Naringoside) is a flavanone glycoside and is a major flavonoid in grapefruit and gives the grapefruit juice its bitter taste.

S2330	Nattokinase	Jan 2011
Nattokinase is an enzyme extracted and purified from a Japanese food called nattō.

S1549	Nebivolol (Bystolic)	Oct 2010
Nebivolol (Bystolic) is a β1 receptor blocker with an IC50 of 4.5 µM.

S1583	Nepicastat(SYN117)	Nov 2010
Nepicastat is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively.

S1808	Nifedipine(Adalat)	Jan 2011
Nifedipine(Adalat), a potent vasodilator agent with calcium antagonistic action.

S1747	Nimodipine(Nimotop)	Dec 2010
Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.

S1748	Nisoldipine (Sular)	Dec 2010
Nisoldipine (Sular) is a calcium channel blocker.

S2491	Nitrendipine	Jan 2011
Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.

S2493	Olanzapine(Zyprexa)	Jan 2011
Olanzapine(Zyprexa) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.

S1587	Olmesartan(Benicar,Olmetec)	Nov 2010
Olmesartan is an angiotensin II receptor antagonist with an IC50 of 7.7 nM.

S2623	Omecamtiv mecarbil (CK-1827452)	Jun 2011
Omecamtiv mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator with an E50 of 0.6 μM.

S2495	Oxymetazoline hydrochloride	Jan 2011
Oxymetazoline hydrochloride is an α1 and α2 adrenergic receptor agonist.

S2496	Ozagrel	Jan 2011
Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM.

S1506	Perindopril Erbumine (Aceon)	Sep 2010
Perindopril Erbumine (Aceon) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.

S2569	Phenylephrine hydrochloride	May 2011
Phenylephrine hydrochloride is a selective α1-adrenergic receptor agonist.

S2343	Phlorizin(Phloridzin)	Jan 2011
Phlorizin(Phloridzin) is a toxic 2'-glucoside of phloretin.

S1550	Pimobendan (Vetmedin)	Oct 2010
Pimobendan (Vetmedin) is a Ca(2+) sensitizer with an IC50 of 26 µM and a selective phosphodiesterase III inhibitor with an IC50 of <1 µM.

S2390	Polydatin (Piceid)	Feb 2011
Polydatin(Piceid), 3,4’,5-trihydroxystilbene-3-β-mono-D-glucoside, the crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.

S1258	Prasugrel (Effient)	May 2010
A novel platelet inhibitor

S2571	Quinidine	May 2011
Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent.

S2161	RAF265 (CHIR-265)	Jan 2011
RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM.

S1793	Ramipril(Altace)	Nov 2010
Ramipril(Altace) is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5 nM.

S1425	Ranolazine dihydrochloride	Jul 2010
Ranolazine(Ranexa), is an antianginal medication.

S1799	Ranolazine(Ranexa)	Nov 2010
Ranolazine(Ranexa) is an antianginal medication.

S1601	Reserpine	Sep 2010
Reserpine is an indole alkaloid antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms.

S3002	Rivaroxaban (Xarelto)	Apr 2009
Rivaroxaban (Xarelto) is a FXa inhibitor, showed a similar affinity to purified human and rabbit FXa (IC50 0.7 ± 0.01 and 0.8 ± 0.01 nM)

S2169	Rosuvastatin calcium(Crestor)	Jan 2011
Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions, and to prevent cardiovascular disease.

S2349	Rutaecarpine(Rutecarpine)	Jan 2011
Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs.

S2019	Sarpogrelate hydrochloride	Jan 2012
Sarpogrelate hydrochloride is a selective 5-HT2A receptor antagonist to 5-HT2A, 5-HT2C and 5-HT2B receptors with pKi of 8.52, 7.43 and 6.57, respectively.

S1431	Sildenafil citrate	Jul 2010
Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).

S2405	Sophocarpine	Mar 2011
Sophocarpine is a human ether-à-go-go-related gene (HERG) inhibitor with an IC(50) of about 0.2 mM.

S2509	Sotalol (Betapace)	Jan 2011
Sotalol (Betapace) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 µM.

S2365	Tanshinone IIA(Tanshinone B)	Jan 2011
Tanshinone IIA(Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases.

S2008	Taurine	Dec 2010
Taurine, or 2-aminoethanesulfonic acid, is an organic acid.

S1738	Telmisartan (Micardis)	Dec 2010
Telmisartan (Micardis) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

S2368	Theobromine(3,7-Dimethylxanthine)	Jan 2011
Theobromine(3,7-Dimethylxanthine) is a xanthine alkaloid that is used as a bronchodilator and as a vasodilator.

S1698	Torsemide(Demadex)	Dec 2010
Torsemide(Demadex) is a pyridine-sulfonyl urea type loop diuretic with an IC50 of 2.7 ± 0.17 µM.

S1554	Travoprost(Travatan)	Oct 2010
Travoprost is a topical medication used for controlling the progression of glaucoma or ocular hypertension.

S2369	Troxerutin	Jan 2011
Troxerutin(Trihydroxyethylrutin) is a flavonol, a type of flavonoid.

S1894	Valsartan (Diovan)	Nov 2010
Valsartan (Diovan) is an angiotensin II receptor antagonist with IC50 of ranging from 39.5 to 116 µM.

S1819	Warfarin sodium	Jan 2011
Warfarin sodium, an anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors.

S2372	Xanthone(Genicide)	Jan 2011
Xanthone is an organic compound. It can be prepared by the heating of phenyl salicylate.

S2273	β-Sitosterol	Jan 2011
β-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol.