YAP-TEAD Inhibitor 1 (Peptide 17)

Catalog No.S8164

YAP-TEAD Inhibitor 1 (Peptide 17) Chemical Structure

Molecular Weight(MW): 2019.86

Peptide 17 is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.

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USD 197 In stock
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Choose Selective Hippo pathway Inhibitors

Biological Activity

Description Peptide 17 is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
Targets
YAP/TEAD interaction [1]
(Cell-free assay)
25 nM
In vitro

The engineered peptide significantly improves the potency in disrupting YAP-TEAD interaction in vitro[1]. This 17mer peptide demonstrates a single-digit micromolar affinity to TEAD1[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Bel-7404 cells M3;MNWZ2dmO2aX;uJIF{e2G7 NXTTc241UW6qaXLpeIlwdiCxZjDZRXAwKEeVVD3USWFFOSCrboTldoFkfGmxbjDpckBpfW2jbjDC[YwuPzRyNDDj[YxteyCkeTDHV3QheHWubD3kc5dvKGG|c3H5MEBM\D1yLkCxOUDPxE1? NYP5XXBmOjV{MkG2OVU>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (49.5 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 2019.86
Formula

C93H144ClN23O21S2

CAS No. no CAS
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    Is this inhibitor cell permeable?

  • Answer:

    The following paper states that the cyclic YAP petide at N terminus may improve the cell permeability: “Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides”

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID