Home Metabolism GluR modulator VU-29 For research use only.

VU-29

VU-29 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor, with EC50 of 9 nM and Ki=244 nM for rat mGluR5, which is selective for mGluR5 relative to other mGluR subtypes.

VU-29 Chemical Structure

VU-29 Chemical Structure

CAS: 890764-36-0

Purity & Quality Control

Batch: S197001 DMSO] 77 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.59%
99.59

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Biological Activity

Description VU-29 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor, with EC50 of 9 nM and Ki=244 nM for rat mGluR5, which is selective for mGluR5 relative to other mGluR subtypes.
Targets
rat mGluR5 [1] rat mGluR5 [1]
9 nM(EC50) 244 nM(Ki)

Chemical Information & Solubility

Molecular Weight 384.39 Formula

C22H16N4O3
CAS No. 890764-36-0 SDF --
Smiles [O-][N+](=O)C1=CC=C(C=C1)C(=O)NC2=CC(=N[N]2C3=CC=CC=C3)C4=CC=CC=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 77 mg/mL ( (200.31 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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