Vitamin C

Synonyms: L-Ascorbic acid

Vitamin C (L-Ascorbic acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy.

Vitamin C Chemical Structure

Vitamin C Chemical Structure

CAS: 50-81-7

Selleck's Vitamin C has been cited by 12 publications

Purity & Quality Control

Batch: Purity: 99.97%
99.97

Vitamin C Related Products

Choose Selective Vitamin Inhibitors

Biological Activity

Description Vitamin C (L-Ascorbic acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy.
In vitro
In vitro

Ascorbate when combined with copper rapidly reduces the viscosity of DNA solutions and has exhibited some carcinostatic effects on transplanted sarcoma 180 tumours in mice. [1]

Exposure of HL-60 cells to increasing concentrations of H2O2 results in dose-dependent intracellular accumulation of peroxides, which is accompanied by a decrease in intracellular ascorbic acid and an increase in apoptosis. Ascorbic acid loading also provides strong protection from apoptosis associated with serum- and glucose-free culture of HL-60 cells. [2]

Vitamin C is found to protect GSH-depleted HL-60 cells in a dose-dependent manner. Vitamin C inhibits the formation of ROS in both normal and GSH-depleted cells. [3]

Ascorbate (1 mM) generates 161 mM H2O2 in Dulbecco's modified Eagle's medium and induces apoptosis in 50% of HL60 cells, whereas in RPMI 1640 only 83 mM H2O2 is produced and no apoptosis is detected. [4]

Cell Research Cell lines Fibroblasts
Concentrations 100 μM
Incubation Time 2 h
Method

Cells were treated with indicated concentration of drug for 2 h.

In Vivo
In vivo

Treatment of rats with Vitamin C 10 min prior to the cisplatin inhibits cisplatin-mediated damage. The enhanced serum creatinine levels which are indicative of renal injury shows a significant reduction with the three doses of Vitamin C tested. [5]

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06032234 Recruiting
Healthy
Isabelle Herter-Aeberli|Berner Fachhochschule|Swiss Federal Institute of Technology
September 12 2023 --
NCT05810233 Recruiting
Rhinitis Allergic|Allergy
National University of Malaysia
July 15 2023 Not Applicable
NCT05975125 Recruiting
Vitamin C Anemia|Pregnancy Anemia
Rajavithi Hospital
June 28 2023 Not Applicable
NCT05501548 Recruiting
Prostate Cancer|Castration-resistant Prostate Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|AstraZeneca|McGuff Pharmaceuticals Inc.|The Marcus Foundation
June 30 2023 Phase 2
NCT05788952 Not yet recruiting
Endometriosis
Universidade Nova de Lisboa|Academia CUF
June 1 2023 --
NCT04505878 Withdrawn
Primary Graft Dysfunction|Lung Transplant; Complications
University of Wisconsin Madison
April 2023 Phase 2

Chemical Information & Solubility

Molecular Weight 176.12 Formula

C6H8O6

CAS No. 50-81-7 SDF Download Vitamin C SDF
Smiles C(C(C1C(=C(C(=O)O1)O)O)O)O
Storage (From the date of receipt) 3 years -20°C powder (seal)

In vitro
Batch:

DMSO : 35 mg/mL ( (198.72 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 35 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Vitamin C | Vitamin C ic50 | Vitamin C price | Vitamin C cost | Vitamin C solubility dmso | Vitamin C purchase | Vitamin C manufacturer | Vitamin C research buy | Vitamin C order | Vitamin C mouse | Vitamin C chemical structure | Vitamin C mw | Vitamin C molecular weight | Vitamin C datasheet | Vitamin C supplier | Vitamin C in vitro | Vitamin C cell line | Vitamin C concentration | Vitamin C nmr