Retinyl (Vitamin A) Palmitate

Synonyms: Vitamin A palmitate

Retinyl (Vitamin A) Palmitate is a more stable, synthetic version of the essential nutrient vitamin A joined to palmitic acid.

Retinyl (Vitamin A) Palmitate Chemical Structure

Retinyl (Vitamin A) Palmitate Chemical Structure

CAS: 79-81-2

Purity & Quality Control

Batch: S412601 Ethanol] 5 mg/mL] false] DMSO] 3 mg/mL] false] Water] Insoluble] false Purity: 99.11%
99.11

Retinyl (Vitamin A) Palmitate Related Products

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Biological Activity

Description Retinyl (Vitamin A) Palmitate is a more stable, synthetic version of the essential nutrient vitamin A joined to palmitic acid.
In vitro
In vitro The microencapsulation of vitamin A palmitate by gelatin-acacia complex is a promising method for converting an oily vitamin to solid powders for an aid to handling and ease of incorporation in preparations. [1]
In Vivo
In vivo Vitamin A Palmitate (80 mg/kg daily p.o.) or (800 mg/kg once a week p.o.) dose-dependently decreases the size of papillomas in mice, the daily administration induces a somewhat higher extent of regression than the weekly application if the total doses are compared. Water miscible solutions of Vitamin A Palmitate as well as of Vitamin A acid given by the oral route elicit the same effect on papillomas. [2] Vitamin A Palmitate (A single simultaneous injection of 150 g) enhances cell-mediated immunity to sheep red blood cells(SRBC) as early as 3 days following immunization, and the enhancement persists for at least 3 weeks. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01958775 Completed
Dyslipidemia
University Health Network Toronto
March 2012 Phase 3
NCT02867488 Completed
Biological Availability
Iowa State University
April 2009 Not Applicable

Chemical Information & Solubility

Molecular Weight 524.86 Formula

C36H60O2

CAS No. 79-81-2 SDF Download Retinyl (Vitamin A) Palmitate SDF
Smiles CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(CCCC1(C)C)C
Storage (From the date of receipt) 2 years  -20°C  liquid

In vitro
Batch:

Ethanol : 5 mg/mL

DMSO : 3 mg/mL ( (5.71 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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