Vacquinol-1

Catalog No.S7544 Synonyms: NSC13316

Vacquinol-1 Chemical Structure

Molecular Weight(MW): 425.78

Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.

Size Price Stock Quantity  
USD 97 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective JNK Inhibitors

Biological Activity

Description Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
Targets
MKK4 [1]
In vitro

Vacquinol-1 induces rapid and specific cell death of glioma cells with IC50 of 3.14 μM via membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture. [1]

In vivo In mice bearing U3013MG tumors, Vacquinol-1 (15 μM intracranial injection, or 20 mg/kg p.o.) attenuates tumor growth and prolonging survival. [1]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: Glioblastoma cells
  • Concentrations: 15 μM
  • Incubation Time: 2 d
  • Method: Cell viability is measured using CellTiter-Glo Luminescent Cell Viability Assay according to the manufacturer’s instructions.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mice bearing U3013MG tumors
  • Formulation: DMSO
  • Dosages: 15 μM or 20 mg/kg
  • Administration: Intracranial injection, i.p., p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 70 mg/mL (164.4 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 425.78
Formula

C21H21ClN2O · 2HCl

CAS No. 5428-80-8(free base)
Storage powder
Synonyms NSC13316

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

JNK Signaling Pathway Map

Related JNK Products

Tags: buy Vacquinol-1 | Vacquinol-1 supplier | purchase Vacquinol-1 | Vacquinol-1 cost | Vacquinol-1 manufacturer | order Vacquinol-1 | Vacquinol-1 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID