Sulfabenzamide

Synonyms: Sultrin, N-Sulfanilylbenzamide

Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.

Sulfabenzamide Chemical Structure

Sulfabenzamide Chemical Structure

CAS: 127-71-9

Purity & Quality Control

Batch: S457601 DMSO] 55 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.64%
99.64

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Biological Activity

Description Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.
In vitro
In vitro Sulfabenzamide inhibits the proliferation and increases Caspase-3 activity in T-47D cells. It dose not induce apoptosis but a minimal shift from G1 to S and G2/M phases of the cell cycle[1].
Cell Research Cell lines T-47D breast cancer cells
Concentrations 0-20 mM
Incubation Time 24, 48 and 72 h
Method The MTT assay is used to evaluate the viability of T-47D cells incubated with different concentrations of sulfabenzamide (0.0-20 mM) or doxorubicin (0.0-0.6 μM) after 24, 48 and 72 h.

Chemical Information & Solubility

Molecular Weight 276.31 Formula

C13H12N2O3S

CAS No. 127-71-9 SDF Download Sulfabenzamide SDF
Smiles C1=CC=C(C=C1)C(=O)NS(=O)(=O)C2=CC=C(C=C2)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 55 mg/mL ( (199.05 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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