Home Ubiquitin E3 Ligase inhibitor Skp2 inhibitor C1 (SKPin C1) For research use only.

Skp2 inhibitor C1 (SKPin C1)

Skp2 inhibitor C1 (SKPin C1) is a specific and selective small-molecule inhibitor of Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.

Skp2 inhibitor C1 (SKPin C1) Chemical Structure

Skp2 inhibitor C1 (SKPin C1) Chemical Structure

CAS: 432001-69-9

Selleck's Skp2 inhibitor C1 (SKPin C1) has been cited by 8 publications

Purity & Quality Control

Batch: S865201 DMSO] 93 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.09%
99.09

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Biological Activity

Description Skp2 inhibitor C1 (SKPin C1) is a specific and selective small-molecule inhibitor of Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.
Targets
p27 degradation [1]
In vitro
In vitro Skp2 inhibitor C1 treatment of MCF-7 breast cancer cells lines does not increase, but rather decrease the percentage of cells in G1 while increasing the G2/M population[1].
Cell Research Cell lines 501 Mel cells
Concentrations 10 μM
Incubation Time 16 h
Method

501 Mel cell lines are pretreated with each inhibitor (10 μM) or 0.1% DMSO (vehicle) for 16 h. Cycloheximide half-life is examined.

Chemical Information & Solubility

Molecular Weight 465.34 Formula

C18H13BrN2O4S2
CAS No. 432001-69-9 SDF --
Smiles C1=CC(=CN=C1)CN2C(=O)C(=CC3=C(C=CC(=C3)Br)OCC(=O)O)SC2=S
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 93 mg/mL ( (199.85 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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