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Sevelamer Carbonate

Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.

Sevelamer Carbonate Chemical Structure

Sevelamer Carbonate Chemical Structure

CAS: 845273-93-0

Purity & Quality Control

Sevelamer Carbonate Related Products

Biological Activity

Description Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.
In vitro
In vitro Sevelamer carbonate is designed as an alternative to sevelamer hydrochloride with enhanced buffering capacity. The sevelamer moiety consists of a carbon backbone with multiple amine groups, each separated from the backbone by a single carbon atom. In the intestine, Sevelamer carbonate become protonated and subsequently bind to dietary phosphorus molecules via ionic and hydrogen interactions. The result of these interactions is a decrease in phosphorus levels within the gastrointestinal tract, resulting in decreased dietary phosphorus absorption and decreased serum phosphorus levels. In addition to the effect on phosphorus levels, the polymeric amine structure of sevelamer has been shown to bind bile acids to reduces total cholesterol levels. [1]
In Vivo
In vivo Sevelamer Carbonate is able to reduce renal failure triggered inflammation and induced endotoxemia in experimental model of chronic kidney disease. [2] Sevelamer carbonate also shows beneficial effects on renal dysfunction, secondary hyperparathyroidism and vascular calcification in rats fed with high-phosphorus diet. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01220843 Completed
Chronic Renal Failure
Centre Hospitalier Universitaire Amiens|Genzyme a Sanofi Company
 October 2010 Phase 3
NCT01191762 Completed
Hyperparathyroidism|Chronic Kidney Disease
Kenneth R. Phelps M.D.|Genzyme a Sanofi Company|Phelps Kenneth R. M.D.
 April 2010 Phase 3
NCT01011699 Terminated
Chronic Renal Failure|Hemodialysis
Centre Hospitalier Universitaire Amiens
 January 2010 Phase 3
NCT00853242 Completed
Kidney Failure Chronic
Genzyme a Sanofi Company|Sanofi
 February 2009 Phase 2

Chemical Information & Solubility

Molecular Weight Formula

(C3H7N.C3H5ClO)x.xCH2O3
CAS No. 845273-93-0 SDF Download Sevelamer Carbonate SDF
Smiles C=CCN.C1C(O1)CCl.C(=O)(O)O
Storage (From the date of receipt)

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

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