NGP 555

Catalog No.S8603

NGP 555 Chemical Structure

Molecular Weight(MW): 406.52

NGP 555 is a small-molecule modulator of γ-secretase and has been successful in achieving good oral absorption, brain penetration, CNS activity, and specificity for a lipid-based membrane target preclinically.

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Biological Activity

Description NGP 555 is a small-molecule modulator of γ-secretase and has been successful in achieving good oral absorption, brain penetration, CNS activity, and specificity for a lipid-based membrane target preclinically.
Targets
γ-secretase [1]
(Cell-free assay)
In vivo NGP 555 has very good brain penetration/absorption, distribution, metabolism, and excretion (ADME) properties. It efficiently crosses the blood-brain barrier, has a brain:plasma ratio of 0.93 (in Tg2576 mice) and shows in vivo efficacy for lowering the biomarker Aβ42 in rodent studies for brain and plasma. Chronic administration of NGP 555 (milled into chow) to Tg2576 mice results in a significant reduction of amyloid plaques[1].

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: SH-SY5Y-APP cells
  • Concentrations: 10 nM-100 μM
  • Incubation Time: 18 h
  • Method:

    SH-SY5Y-APP cells are treated with various concentrations of NGP 555 or NGP 328, in triplicate wells, for 18 hours. Media is collected and analyzed for Aβ peptides using Meso Scale triplex ELISA (Aβ38, Aβ40, and Aβ42) and total Aβ ELISA.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Sprague-Dawley male rats
  • Formulation: 80% PEG
  • Dosages: 0-37.5 mg/kg
  • Administration: oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 40 mg/mL (98.39 mM)
Ethanol 3 mg/mL (7.37 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 406.52
Formula

C23H23FN4S

CAS No. 1304630-27-0
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Gamma-secretase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID