Home Transmembrane Transporters Proton Pump inhibitor - ATPase inhibitor Esomeprazole magnesium For research use only.

Esomeprazole magnesium

Synonyms: NEXIUM

Esomeprazole Magnesium(NEXIUM) is a proton pump inhibitor to reduce gastric acid secretion through inhibition of H(+)/K(+)-ATPase in gastric parietal cells.

Esomeprazole magnesium Chemical Structure

Esomeprazole magnesium Chemical Structure

CAS: 161973-10-0

Purity & Quality Control

Batch: Purity: 99.90%
99.90

Esomeprazole magnesium Related Products

Signaling Pathway

Proton Pump Signaling Pathways

Proton Pump Signaling Pathway

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Biological Activity

Description Esomeprazole Magnesium(NEXIUM) is a proton pump inhibitor to reduce gastric acid secretion through inhibition of H(+)/K(+)-ATPase in gastric parietal cells.
Targets
H(+)/K(+)-ATPase [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02477475 Completed
Reflux Esophagitis
AstraZeneca
 July 7 2015 --
NCT02277886 Unknown status
Gastroesophageal Reflux Disease|Heartburn|Sleep Disturbance
Chang Gung Memorial Hospital|TTY Biopharm
 November 2014 Phase 4
NCT01130935 Completed
Gastric Acid Suppression|Proton Pump Inhibitors
AstraZeneca
 May 2010 --
NCT01135472 Completed
Healthy
City of Hope Medical Center
 March 2010 Phase 1
NCT00332748 Terminated
Cancer
Bristol-Myers Squibb
 December 2006 Phase 1

Chemical Information & Solubility

Molecular Weight 713.12 Formula

C34H36MgN6O6S2
CAS No. 161973-10-0 SDF Download Esomeprazole magnesium SDF
Smiles CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Mg+2]
Storage (From the date of receipt)

In vitro
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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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