Nefopam HCl
Catalog No.S4180
Molecular Weight(MW): 289.8
Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.
Purity & Quality Control
Choose Selective Sodium Channel Inhibitors
Biological Activity
| Description | Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake. |
|---|---|
| In vitro |
The mechanism of analgesia is not completely understood, it appears that nefopam is a centrally acting, non-opioid analgesic that inhibits reuptake of serotonin, norepinephrine, and dopamine. [1] |
| In vivo | Using the tail-flick and hot-plate assays, nefopam is tested for analgesic activity following intraperitoneal (i.p.), intracranial (i.c.) and intraspinal (i.s.) injection in mice. Nefopam is one-third as potent as morphine on the hot-plate test, but does not affect the tail-flick. . [2] |
Protocol
Solubility (25°C)
| In vitro | Water | 21 mg/mL (72.46 mM) |
|---|---|---|
| DMSO | 1 mg/mL (3.45 mM) | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 289.8 |
|---|---|
| Formula | C17H19NO.HCl |
| CAS No. | 23327-57-3 |
| Storage | powder |
| Synonyms | N/A |
Bio Calculators
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Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02949310 | Recruiting | Breast Neoplasm Malignant Primary | Seoul National University Bundang Hospital | September 2016 | -- |
| NCT02577068 | Not yet recruiting | Thyroidectomy|Pain | Yonsei University | October 2015 | -- |
| NCT02441673 | Not yet recruiting | Post Anaesthetic Shivering | Lagos State Health Service Commission | September 2015 | Phase 2 |
| NCT02561494 | Completed | Stomach Neoplasms | Seoul National University Bundang Hospital | June 2015 | -- |
| NCT02561468 | Completed | Breast Neoplasm | Seoul National University Bundang Hospital | April 2015 | -- |
| NCT02493231 | Recruiting | Cholecystitis | Hallym University Kangnam Sacred Heart Hospital | March 2015 | Phase 4 |
Tech Support
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