Lovastatin

Catalog No.S2061 Synonyms: MK-803

Lovastatin Chemical Structure

Molecular Weight(MW): 404.54

Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent).

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 170 In stock
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1 Customer Review

  • To evaluate the role of cell cycle progression in androgen induced DSB formation, LAPC4 cells were either treated with solvent control or 50 μM lovastatin for 36 h prior to stimulation with 100 nM DHT for 6 h. Note that androgen induced γH2A.X foci formation was not different between control and lovastatin pre-treated cells.

    Clin Cancer Res, 2016, 22(13):3310-3319. Lovastatin purchased from Selleck.

Purity & Quality Control

Choose Selective HMG-CoA Reductase Inhibitors

Biological Activity

Description Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent).
Targets
HMG-CoA reductase [1]
(Cell-free assay)
3.4 nM
In vitro

Lovastatin inhibits LPS- and cytokine-mediated production of NO and expression of iNOS in rat primary astrocytes. Lovastatin inhibits LPS-induced expression of TNF-alpha, IL-1beta, and IL-6 in rat primary astrocytes, microglia, and macrophages. [1] Lovastatin results in over 95% inhibition of DNA synthesis as measured by incorporation of [3H]thymidine into DNA. Lovastatin synchronizes cells in the G1 and not in the G0 phase of the cell cycle. Lovastatin has a similar growth-inhibitory activity against ras-dependent as well as ras-independent cell lines. [2] Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglyc- erides, and a small increase in HDL cholesterol. [3] Lovastatin arrests cells by inhibiting the proteasome, which results in the accumulation of p21 and p27, leading to G1 arrest. Lovastatin is an inhibitor of hydroxymethyl glutaryl (HMG)-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Lovastatin can be used to arrest cultured cells in the G1 phase of the cell cycle, resulting in the stabilization of the cyclin-dependent kinase inhibitors (CKIs) p21 and p27. [4] Lovastatin (2-10 mM) arrests cells in G1 and also prolonged--or arrested a minor fraction of cells in--the G2 phase of the cell cycle in human bladder carcinoma T24 cell line expressing activated p21ras. Lovastatin (50 mM) is cytotoxic in human bladder carcinoma T24 cell line expressing activated p21ras. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEP G2 cells NGC5O4RHfW6ldHnvckBie3OjeR?= NG\3U5ZKdmirYnn0bY9vKG:oIHPlcIx2dGG{IFjNS{1Ed0FicnXkeYN1[XOnIHnuJIN2dHS3cnXzJI9nKGincHH0bYMh[2WubIOgLGhGWCCJMjygZUBpfW2jbjDo[ZBifG:vYTDj[YxtKGyrbnWpMEBKSzVyPUXlMVA2KM7:TR?= MXuyNVU{OjF|
HES 9 cell line M1vofmZ2dmO2aX;uJIF{e2G7 NUDDO2Z5S2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JGhOTy2Fb1GgdoVlfWO2YYPlJIJ6KDVyJTD3ZZMh\GW2ZYLtbY5m\CCrbjDISXMhQSClZXzsJIxqdmVuIFnDOVA:OC5yMUOg{txO NHjwbJEyPTJ5N{mx
HEP G2 cells MkXzSpVv[3Srb36gZZN{[Xl? MXHU[ZN1\WRiZn;yJIlvcGmkaYTpc44hd2ZiY3jvcIV{fGW{b3ygZolwe3mwdHjld4l{KGmwIFjFVEBIOiClZXzsd{whUUN3ME2wMlAzQSEQvF2= NFrsTmw4QTN{NUWx
human SW480 cells Mk\2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MknjPVYhcA>? NE\IbmJIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUXzR6MDDj[YxteyCjZoTldkA6PiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwQVcvOSEQvF2= MX:xO|Q4Ojl4Mh?=
human HepG2 cells MUHGeY5kfGmxbjDhd5NigQ>? MV:2JIg> MU\MbZBq\CCub4fldolv\yCjY4Tpeol1gSCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCxbHXpZ{Bi[2mmIHXsbYNqfGWmIHzpdIllKGGlY4XteYxifGmxbjDh[pRmeiB4IHjyd{BjgSCxaXytdoVlKE9ic4ThbY5qdmdibXX0bI9lNCCLQ{WwQVgvOyEQvF2= NFnvVI0zPjF4OUGyOS=>
human A549 cells NE\kWlBEgXSxdH;4bYPDqGG|c3H5 NHHFeHk4OiCq NV\GUoxYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVEyNjRizszN MVOyN|U4ODV2Mh?=
human HS68 cells M{L1XmN6fG:2b4jpZ:Kh[XO|YYm= M3v4U|czKGh? M1HacWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhUPjhiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yN{4zKM7:TR?= M336[FI{PTdyNUSy
mouse MEF cells NFjsZWdEgXSxdH;4bYPDqGG|c3H5 MoPIO|IhcA>? NVrheW1DS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhVUWIIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9N|Uh|ryP NXm1eG5iOjN3N{C1OFI>
human HT29 cells NEXSZ5RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmrwPVYhcA>? NWPKVlR[T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUFR{OTDj[YxteyCjZoTldkA6PiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwQVQ3NjhizszN NVjScXBjOTd2N{K5OlI>
human SW480 cells MoK3SpVv[3Srb36gZZN{[Xl? NEfnRYIzOCEQvF2= NGjXR|FKdmirYnn0bY9vKG:oIF\CV{1{fGmvdXzheIVlKGmwY4LlZZNmKGmwIFHreEBxcG:|cHjvdplt[XSrb36gbY4hcHWvYX6gV3c1QDBiY3XscJMh[XRiMkCgeW0h[nliaX3teY5w[myxdDDhcoFtgXOrcx?= MmDmNVc1PzJ7NkK=
human RPMI8226 cells MYjBdI9xfG:|aYOgZZN{[Xl? Mo\wNlAh|ryP MmjwOFghcA>? NF3BW2ZKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIGLQUWk5OjJ4IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJINie3Cjc3WtN{BkdGWjdnHn[UBifCB{MDD1UUBqdmO3YnH0[YQh\m:{IES4JIhzeyCkeTDpcY12dm:kbH;0JI1mfGixZB?= NYTu[I5FOjV7M{W2OFM>
human MDA-MB-468 cells NEj5T3RHfW6ldHnvckBie3OjeR?= M{G2NFQ5KGh? M1PTPXRwfGGuIHfyc5d1cCCrbnjpZol1cW:wIH;mJHBTNCCHUjygTGVTOi2wZXfheIl3\SCqdX3hckBOTEFvTVKtOFY5KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDXV3QuOSCjc4PhfS=> NFj0RXUzPDV3NkWwOC=>
human MDA-MB-361 cells  MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYnVdHVVPDhiaB?= M{niZWdzd3e2aDDpcohq[mm2aX;uJI9nKEWULYDvd4l1cX[nLDDISXIzNXCxc3n0bZZmKGi3bXHuJG1FSS2PQj2zOlEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGfTWE0yKGG|c3H5 M1PUSlI1PTV4NUC0
human AU565 cells NV\vUXg6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlP3OFghcA>? NXXFR4J7T3Kxd4ToJIlvcGmkaYTpc44hd2ZiRWKtcoVo[XSrdnWsJGhGWjJvcH;zbZRqfmViaIXtZY4hSVV3NkWgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFeVVD2xJIF{e2G7 M{HoXlI1PTV4NUC0
human MCF7 cells M1nT[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3\hVVQ5KGh? MYrUc5RidCCpcn;3eIghcW6qaXLpeIlwdiCxZjDFVk1xd3OrdHn2[UwhUEWUMj3u[YdifGm4ZTDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCZU2StNUBie3OjeR?= M4rHZlI1PTV4NUC0
human MDA-MB-231 cells M1HFW2Z2dmO2aX;uJIF{e2G7 MW[yOEBp MV3JcoR2[3Srb36gc4YheDJzIHX4dJJme3Orb36gbY4hcHWvYX6gVHItKEWULDDISXIzNW6nZ3H0bZZmKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZQhOSC2bzCxNEB2VSCjZoTldkAzPCCqcoOgZpkhf2W|dHXyckBjdG:2IHHuZYx6e2m| MWeyOFU2PjVyNB?=
human LS180 cells MWPGeY5kfGmxbjDhd5NigQ>? MUeyNEDPxE1? NH\XSm9KdmirYnn0bY9vKG:oIIP1dpZqfmmwIHX4dJJme3Orb36gbY4heGG{ZX70JIh2dWGwIFzTNVgxKGOnbHzzJIF1KDJyIIXNJIJ6KGmvbYXuc4Jtd3RiYX7hcJl{cXN? MUKxO|Q4Ojl4Mh?=
human K562 cells NFnPR2pHfW6ldHnvckBie3OjeR?= NXPoT4pqPDhiaB?= M{OxN2lvcGmkaYTpc44hd2ZiR1fUZZNmOSCrbjDoeY1idiCNNU[yJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCUYYCxZUBxem:2ZXnuJIdmemGweXzn[ZJidnmuYYTpc44h[W[2ZYKgOFghcHK|IHL5JHdme3Sncn6gZoxwfHSrbne= Mo\vNlA5OzJ|Mk[=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 8 mg/mL (19.77 mM)
Ethanol 6 mg/mL (14.83 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 404.54
Formula

C24H36O5

CAS No. 75330-75-5
Storage powder
in solvent
Synonyms MK-803

Bio Calculators

Molarity Calculator

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00092846 Completed Hypercholesterolemia Merck Sharp & Dohme Corp. December 4 2002 Phase 3
NCT03510884 Recruiting Hypercholesterolaemia Sanofi|Regeneron Pharmaceuticals May 31 2018 Phase 3
NCT03178526 Completed Alveolar Bone Loss Chronic Periodontitis Lovestatin Gel Regeneration Islamic Azad University Tehran December 24 2015 Phase 2|Phase 3
NCT03510715 Recruiting Hypercholesterolemia Sanofi|Regeneron Pharmaceuticals August 22 2018 Phase 3
NCT03504501 Recruiting Impaired Synaptic Plasticity|Impaired Cognition Technische Universität München May 2018 Phase 2
NCT02964884 Recruiting Neurofibromatosis Type 1|Learning Disability|Reading Disability|NF1 Vanderbilt University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) November 2016 Phase 2

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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HMG-CoA Reductase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID