Catalog No.S4849 Synonyms: Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride
Molecular Weight(MW): 461.81
Levocetirizine is the active R-enantiomer of cetirizine and represents a new second-generation histamine H1 antagonist.
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Choose Selective Histamine Receptor Inhibitors
|Description||Levocetirizine is the active R-enantiomer of cetirizine and represents a new second-generation histamine H1 antagonist.|
Levocetirizine is a selective antihistaminic that acts through H1 receptor. Levocetirizine inhibits eotaxin-induced eosinophil transendothelial migration through monolayers of human dermal or lung microvascular endothelial cells in vitro. The drug also inhibits both resting and granulocyte-macrophage colony-stimulating factor (GM-CSF)-stimulated eosinophil adhesion to vascular cell adhesion molecule-1 (VCAM-1), eotaxin production by endothelial cells and ICAM-1, as well as major histocompatability complex (MHC) class I expression by interferon (IFN)-γ-stimulated keratinocytes.
|In vivo||In vivo, levocetirizine has rapid absorption and high bioavailability, a low potential for drug interactions, low-volume distribution and a lack of effects on cognition, psychomotor function or the cardiovascular system. Levocetirizine improves renal function in diabetic rat. It attenuates the elevated renal levels of TNF-α and TGF-β1, ameliorates renal oxidative stress and restores NO bioavailability in diabetic kidney. Levocetirizine elicits vasculoprotective and renoprotective effects in experimental diabetes.|
|In vitro||DMSO||92 mg/mL (199.21 mM)|
|Water||92 mg/mL (199.21 mM)|
|Ethanol||7 mg/mL (15.15 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride|
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