LCZ696

Catalog No.S7678 Synonyms: Sacubitril, Valsartan

LCZ696 Chemical Structure

Molecular Weight(MW): 915.98

LCZ696, consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.

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Biological Activity

Description LCZ696, consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.
Targets
RAAS [1]
In vivo In double-transgenic rats overexpressing human renin and angiotensinogen and plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) induces a dose-dependent and long-lasting reduction in mean arterial pressure (MAP), and stimulates a rapid and dose-dependent augmentation of plasma ANP immunoreactivity. [1] In rat myocardial infarction (MI) model, LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy. [2]

Protocol

Animal Research:

[2]

+ Expand
  • Animal Models: Double-transgenic rats overexpressing human renin and angiotensinogen and plasma atrial natriuretic peptide immunoreactivity
  • Formulation: --
  • Dosages: ~60 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro Water 100 mg/mL warmed (109.17 mM)
DMSO 30 mg/mL warmed (32.75 mM)
Ethanol 9 mg/mL warmed (9.82 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 915.98
Formula

C24H29N5O3.C24H29NO5.5/2H2O.3Na

CAS No. 936623-90-4
Storage powder
Synonyms Sacubitril, Valsartan

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02816736 Not yet recruiting Heart Failure Duke University|National Heart, Lung, and Blood Institute (NHLBI) February 2017 Phase 4
NCT02924727 Recruiting Acute Myocardial Infarction Novartis Pharmaceuticals|Novartis December 2016 Phase 3
NCT02900378 Recruiting Chronic Heart Failure With Reduced Ejection Fraction Novartis Pharmaceuticals|Novartis December 2016 Phase 3
NCT02970669 Recruiting Heart Failure, Reduced Ejection Fraction Novartis Pharmaceuticals|Novartis December 2016 Phase 4
NCT02884206 Recruiting Heart Failure Novartis Pharmaceuticals|Novartis November 2016 Phase 3
NCT02678312 Recruiting Pediatric Heart Failure Novartis Pharmaceuticals|Novartis November 2016 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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