L-Arginine HCl (L-Arg)

Catalog No.S3174

L-Arginine HCl (L-Arg) Chemical Structure

Molecular Weight(MW): 210.66

L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

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Biological Activity

Description L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
In vitro

L-Arginine (0.3 mM, 30 minutes) supplementation do not induce any significant increases in the peak NO concentration at low level of native LDL. However, at native LDL concentrations from 60-130 mg cholesterol/dL, NO concentration is 2 times higher than before L-Arginine treatment in bovine aortic endothelial cells. L-Arginine (0.3 mM, 30 minutes) pretreatment results in a significant increase of NO production in n-LDL–treated cells as well as in oxidized -LDL–treated cells in bovine aortic endothelial cells. L-Arginine (0.3 mM, 30 minutes) does not increase O2- concentration at low nativeLDL concentrations but reduce O2- production by 50% when incubate with n-LDL at concentrations >40 mg cholesterol/dL in bovine aortic endothelial cells. L-Arginine (0.3 mM, 30 minutes) pretreatment completely abolishes O2- production at every oxidized LDL dosage in bovine aortic endothelial cells. [1]

In vivo L-Arginine (4 mg/kg/min for 1 hour) treatment decreases superoxide generation by cNOS while increasing NO accumulation in rabbit limb during ischemia/reperfusion. L-Arginine (4 mg/kg/min for 1 hour) prevents microvessel constriction in the reperfused muscle despite reduced but still apparent interstitial edema in rabbit limb. L-Arginine (4 mg/kg/min for 1 hour) treatment results in a significant reduction of muscular reperfusion edema in rabbit limb. [2] L-Arginine (0.1 g/kg, oral) supplementation significantly reduces pulmonary artery systolic pressure by a mean of 15.2% after 5 days of therapy in patients with sickle cell disease. Both L-Arginine and ornithine concentrations increased significantly after 5 days of oral L-Arginine (0.1 g/kg) supplementation in patients with sickle cell disease. [3] L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. [4] L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice. [5]

Protocol

Solubility (25°C)

In vitro Water 42 mg/mL (199.37 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 210.66
Formula

C6H14N4O2.HCl

CAS No. 1119-34-2
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02882373 Not yet recruiting Hypertensive Diseases|Renal Failure M.D. Anderson Cancer Center December 2016 --
NCT02894723 Not yet recruiting Hypertension Meir Medical Center September 2016 Phase 4
NCT02869204 Not yet recruiting Wound Infection and Wound Healing Jens Rikardt Andersen|Rigshospitalet, Denmark|University of Copenhagen September 2016 --
NCT02838030 Not yet recruiting High Risk Pregnancy University of Guadalajara|PhD Ernesto Javier Ramírez Lizardo|PhD Sylvia Elena Totsuka Sutto|PhD Fernando Grover Páez|MD Diego Hernández Molina July 2016 Phase 2
NCT02536170 Recruiting Sickle Cell Disease|Vaso-occlusive Pain Episode Emory University|Childrens Healthcare of Atlanta February 2016 Phase 2
NCT02850367 Recruiting Physiology University Hospital, Grenoble February 2015 --

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