L-Arginine HCl (L-Arg)
Molecular Weight(MW): 210.66
L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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|Description||L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.|
L-Arginine (0.3 mM, 30 minutes) supplementation do not induce any significant increases in the peak NO concentration at low level of native LDL. However, at native LDL concentrations from 60-130 mg cholesterol/dL, NO concentration is 2 times higher than before L-Arginine treatment in bovine aortic endothelial cells. L-Arginine (0.3 mM, 30 minutes) pretreatment results in a significant increase of NO production in n-LDL–treated cells as well as in oxidized -LDL–treated cells in bovine aortic endothelial cells. L-Arginine (0.3 mM, 30 minutes) does not increase O2- concentration at low nativeLDL concentrations but reduce O2- production by 50% when incubate with n-LDL at concentrations >40 mg cholesterol/dL in bovine aortic endothelial cells. L-Arginine (0.3 mM, 30 minutes) pretreatment completely abolishes O2- production at every oxidized LDL dosage in bovine aortic endothelial cells. 
|In vivo||L-Arginine (4 mg/kg/min for 1 hour) treatment decreases superoxide generation by cNOS while increasing NO accumulation in rabbit limb during ischemia/reperfusion. L-Arginine (4 mg/kg/min for 1 hour) prevents microvessel constriction in the reperfused muscle despite reduced but still apparent interstitial edema in rabbit limb. L-Arginine (4 mg/kg/min for 1 hour) treatment results in a significant reduction of muscular reperfusion edema in rabbit limb.  L-Arginine (0.1 g/kg, oral) supplementation significantly reduces pulmonary artery systolic pressure by a mean of 15.2% after 5 days of therapy in patients with sickle cell disease. Both L-Arginine and ornithine concentrations increased significantly after 5 days of oral L-Arginine (0.1 g/kg) supplementation in patients with sickle cell disease.  L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively.  L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice. |
-  Vergnani L, et al. Circulation, 2000, 01(11), 1261-1266.
-  Huk I, et al. Circulation, 1997, 96(2), 667-675.
-  Morris CR, et al. Am J Respir Crit Care Med, 2003, 168(1), 63-69.
|In vitro||Water||42 mg/mL (199.37 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02882373||Not yet recruiting||Hypertensive Diseases|Renal Failure||M.D. Anderson Cancer Center||December 2016||--|
|NCT02894723||Not yet recruiting||Hypertension||Meir Medical Center||September 2016||Phase 4|
|NCT02869204||Not yet recruiting||Wound Infection and Wound Healing||Jens Rikardt Andersen|Rigshospitalet, Denmark|University of Copenhagen||September 2016||--|
|NCT02838030||Not yet recruiting||High Risk Pregnancy||University of Guadalajara|PhD Ernesto Javier Ramírez Lizardo|PhD Sylvia Elena Totsuka Sutto|PhD Fernando Grover Páez|MD Diego Hernández Molina||July 2016||Phase 2|
|NCT02536170||Recruiting||Sickle Cell Disease|Vaso-occlusive Pain Episode||Emory University|Childrens Healthcare of Atlanta||February 2016||Phase 2|
|NCT02850367||Recruiting||Physiology||University Hospital, Grenoble||February 2015||--|
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