K02288

Catalog No.S7359

K02288 Chemical Structure

Molecular Weight(MW): 352.38

K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.

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Biological Activity

Description K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.
Features A chemical probe for BMP signaling in cells.
Targets
ALK2 [1]
(Cell-free assay)
ALK1 [1]
(Cell-free assay)
ALK6 [1]
(Cell-free assay)
ALK3 [1]
(Cell-free assay)
1.1 nM 1.8 nM 6.4 nM 34.4 nM
In vitro

K02288 dose-dependently inhibits BMP4- and BMP6- induced Smad1/5/8 phosphorylation in C2C12 cells without affecting TGF-β-BMP signaling. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse C2C12 cells MWPGeY5kfGmxbjDhd5NigQ>? NF\lW3o{OCCvaX7z MUDJcohq[mm2aX;uJI9nKEKPUEKtbY5lfWOnZDDCUXAhemWlZYD0c5IhfHmyZTCxJGFNUzJiaX6gcY92e2ViQ{LDNVIh[2WubIOgZYZ1\XJiM{CgcYlveyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NE4zOyEQvF2= M1fnN|I2OTBzOUGx
HEK293T cells NFTweWpHfW6ldHnvckBie3OjeR?= NGK5dpQ{OCCvaX7z Mo\MTY5pcWKrdHnvckBw\iCWR1\i[ZRiOS2rbnT1Z4VlKFSJRnLleIEhfHmyZTCxJGFNUzViaX6gTGVMOjl|VDDj[YxteyCjZoTldkA{OCCvaX7zJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1|LkSg{txO M37vWlI2OTBzOUGx

... Click to View More Cell Line Experimental Data

In vivo In Zebrafish Embryos, K02288 induces a dorsalized phenotype in a dose dependent manner without effect om intersomitic vessel (ISV) formation. [1]

Protocol

Animal Research:

[1]

+ Expand
  • Animal Models: Zebrafish Embryos
  • Formulation: DMSO
  • Dosages: ~10 µM
  • Administration: --
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 70 mg/mL (198.64 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 352.38
Formula

C20H20N2O4

CAS No. 1431985-92-0
Storage powder
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID