Histamine 2HCl

Catalog No.S4118

Histamine 2HCl Chemical Structure

Molecular Weight(MW): 184.07

Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.

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In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.
Targets
Histamine H1 receptor [3] Histamine H2 receptor [1]
In vitro

Histamine suppresses the generation of ROS through the Histaminetype-2 receptor (H2 receptor).[1] Histamine inhibits the generation and release of reactive oxygen species (ROS) by monocytes/macrophages (MO) during respiratory burst. Histamine and interleukin-2 (IL-2) act synergistically to activate NK cell cytotoxicity (NKCC). Histamine combined with IL-2 might improve response rates and disease-free survival by protecting the cells of the immune system from oxidative stress and inducing natural endogenous immune cytotoxicity. [2]

In vivo Histamine treatment (0.5 mg/kg or 5.0 mg/kg, twice daily) protects against liver injury as evident by normal serum transaminase levels and significantly reduced liver pathology scores in a rat model with early alcohol-induced liver injury. The protective effect of histamine is blocked by Ranitidine (10 mg/kg), an H2 receptor antagonist, indicating that the histamine effect is predominantly mediated through the H2 receptor. [1] Histamine (30 pg/rat, icv) increases both 3,4-dihydroxyphenylalanine accumulation and 3,4-dihydroxyphenylalanine acid concentrations in the nucleus accumbens in male rats, and this effect is not affect by H2 antagonist zolantidine, indicating that histamine stimulates mesolimbic DA neurons through an action at the H1 receptor. [3] Histamine (0.5 mg/kg s.c.) reduces the liver tumour weight by 46% and subcutaneous tumour weight by 41% versus rats receiving subcutaneous saline injections. The anti-tumour effect observed by subcutaneous histamine injections is inhibited by Ranitidine (50 mg/kg s.c.) in rats sarcoma. [4] Histamine (1000 mg/kg s.c.) displays acute tissue damage after 24 hours and indications of pathological inflammation at the injection sites at 5 days and 28 days in Sprague-Dawley rats. Histamine (1000 mg/kg s.c.) results in Cmax of 167 mM, tmax of 0.5 hour, t1/2 of 0.95 and AUC of 186 mmol-h/L in male Sprague-Dawley rats. [5]

Protocol

Solubility (25°C)

In vitro Water 37 mg/mL (201.01 mM)
DMSO 3 mg/mL (16.29 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 184.07
Formula

C5H9N3.2HCl

CAS No. 56-92-8
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03050866 Not yet recruiting Circulating Tumor Cell|Metastatic Prostate Cancer Erasmus Medical Center|Sanofi February 2017 Phase 2
NCT02882217 Recruiting Asthma EURRUS Biotech GmbH August 2016 Phase 1
NCT02905019 Recruiting Malaria University of Oxford August 2016 Phase 1|Phase 2
NCT02889159 Recruiting Photoaged Skin|Normal Skin University of Michigan June 2016 --
NCT02613910 Terminated Pemphigus GlaxoSmithKline December 2015 Phase 3
NCT02021474 Unknown status Migraine Prophylaxis BioHealthonomics Inc. September 2015 Phase 2

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Histamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID