Fluorometholone Acetate
Catalog No.S4228 Synonyms: NSC 47438
Molecular Weight(MW): 418.5
Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
Purity & Quality Control
Choose Selective Glucocorticoid Receptor Inhibitors
Biological Activity
| Description | Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. | |
|---|---|---|
| Targets |
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| In vitro |
Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. [1] |
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| In vivo | Hourly topical administration of the drug suspension produces an average reduction of 46.8% in the polymorphonuclear leukocytes invading the corneal stroma. In the cornea, fluorometholone acetate appears to have a greater efficacy, as compared to fluorometholone alcohol, for reducing the number of leukocytes invading that tissue following an inflammatory stimulus. Animal toxicity studies of fluorometholone, including acute intraperitoneal LD50s in mice and rats, subacute oral toxicity in rats and dogs, and subacute topical ocular toxicity in rabbits have demonstrated the safety of this drug for human use. [2] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 83 mg/mL (198.32 mM) |
|---|---|---|
| Water | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 418.5 |
|---|---|
| Formula | C24H31FO5 |
| CAS No. | 3801-06-7 |
| Storage | powder |
| Synonyms | NSC 47438 |
Bio Calculators
Molarity Calculator
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02974387 | Not yet recruiting | Must be PRK Candidate | Dr Salouti Eye Research Center|Shiraz University of Medical Sciences | April 2017 | Phase 4 |
| NCT02816905 | Completed | Intraocular Pressure | Cairo University | October 2015 | Phase 4 |
| NCT02030990 | Recruiting | Corneal Opacity | United States Naval Medical Center, San Diego | August 2014 | Phase 2|Phase 3 |
| NCT01949454 | Completed | Trichiasis|Trachoma|Bilamellar Tarsal Rotation | University of Pennsylvania|Lions Clubs International Foundation (funding)|Berhan Public Health and Eye Care Consultancy PLC|Grarbet Tehadiso Mahber | November 2013 | -- |
| NCT01448213 | Completed | Fuchs Dystrophy|Bullous Keratopathy | Price Vision Group | October 2011 | Phase 2 |
| NCT00824811 | Withdrawn | Epiphora | M.D. Anderson Cancer Center|Allergan | June 2009 | Phase 2 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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