FIN56

Catalog No.S8254

FIN56 Chemical Structure

Molecular Weight(MW): 517.66

FIN56 is a specific inducer of ferroptosis .

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Choose Selective Ferroptosis Inhibitors

Biological Activity

Description FIN56 is a specific inducer of ferroptosis .
Targets
Ferroptosis [1]
()
In vitro

FIN56 is a specific inducer of ferroptosis. The mechanism involves two distinct pathways: one pathway is degradation of GPX4, which requires the enzymatic activity of acetyl-CoA carboxylase; the other pathway is activation of squalene synthase, which leads to coenzyme Q10 depletion, in a manner independent of GPX4 degradation[1].

Protocol

Cell Research:

[1]

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  • Cell lines: HT-1080 cells
  • Concentrations: 5 μM
  • Incubation Time: 10 h
  • Method:

    500,000 HT-1080 cells are seeded in a 10-cm dish. Cells are grown at 37 °C for 16 h. On the day of the analysis, cells are cotreated with 100 μM α-tocopherol and either vehicle (DMSO) or a ferroptosis inducer (10 μM erastin, 0.5 μM (1S, 3R)-RSL3, or 5 μM FIN56) and incubated for 10 h. Cells are then trypsinized, pelleted, washed once with 400 μL of ice-cold PBS containing 1 mM EDTA, and sonicated. After the cell debris have been pelleted and removed, both oxidized and reduced glutathione in 120 μL of sample is quantified in technical triplicates. The glutathione quantity is normalized to the protein concentration measured via Bradford assay.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (193.17 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 517.66
Formula

C25H31N3O5S2

CAS No. 1083162-61-1
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID