Home Transmembrane Transporters Calcium Channel inhibitor - Ras inhibitor Fendiline hydrochloride For research use only.

Fendiline hydrochloride

Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.

Fendiline hydrochloride Chemical Structure

Fendiline hydrochloride Chemical Structure

CAS: 13636-18-5

Purity & Quality Control

Batch: S527901 DMSO] 70 mg/mL] false] ] ] false] ] ] false Purity: 99.86%
99.86

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Signaling Pathway

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Calcium Channel Signaling Pathway

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Biological Activity

Description Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.
Targets
K-ras [1] L-type calcium channel [1]
In vitro
In vitro Fendiline, an L-type calcium channel blocker, is a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras. Fendiline does not inhibit K-Ras posttranslational processing but significantly reduced nanoclustering of K-Ras and redistributed K-Ras from the plasma membrane to the endoplasmic reticulum (ER), Golgi apparatus, endosomes, and cytosol. Fendiline significantly inhibited signaling downstream of constitutively active K-Ras and endogenous K-Ras signaling in cells transformed by oncogenic H-Ras. Consistent with these effects, fendiline blocked the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras[1].
Cell Research Cell lines MDCK cells
Concentrations --
Incubation Time 48 h
Method

MDCK cells stably expressing GFP-K-RasG12V were treated with 1% vehicle (DMSO) or various concentrations of fendiline for 48 h. Cells were trypsinized and resuspended in medium. Ten microliters of cell suspension was mixed with 10 μl of 0.4% trypan blue, and live/dead cell counts were obtained using Countess.

Chemical Information & Solubility

Molecular Weight 351.91 Formula

C23H25N.HCl
CAS No. 13636-18-5 SDF --
Smiles CC(C1=CC=CC=C1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 70 mg/mL ( (198.91 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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