Ethosuximide
Catalog No.S4626
Molecular Weight(MW): 141.17
Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker.
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Biological Activity
| Description | Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker. |
|---|---|
| In vitro |
Ethosuximide(ETH) enhances hippocampal derived NSC proliferation and neurospheres formation in vitro. Low concentration of ETH induces proliferation of NSC, while higher concentrations of ETH are cytotoxic. Also, ETH activates the PI3K/Akt signal transduction pathway in adult hippocampal NSC in vitro. Blockade of the PI3K/Akt pathway inhibits ETH induced hippocampal NSC neuronal differentiation[3]. |
| In vivo | Anti-epileptic drug ethosuximide rescues the short lifespan and chemosensory defects exhibited by C. elegans null mutants of dnj-14, the worm orthologue of the DNAJC5 gene mutated in autosomal-dominant adult-onset neuronal ceroid lipofuscinosis. It also ameliorates the locomotion impairment and short lifespan of worms expressing a human Tau mutant that causes frontotemporal dementia[1]. Ethosuximide extends lifespan by inhibiting the function of specific chemosensory neurons[2]. It increases neurogenesis, reduces neurodegeneration, and reverses cognitive impairments in rat model of AD like phenotypes[3]. |
Protocol
| Cell Research: |
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Solubility (25°C)
| In vitro | DMSO | 28 mg/mL (198.34 mM) |
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| Water | 28 mg/mL (198.34 mM) | |
| Ethanol | 28 mg/mL (198.34 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 141.17 |
|---|---|
| Formula | C7H11NO2 |
| CAS No. | 77-67-8 |
| Storage | powder |
| Synonyms | N/A |
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