Catalog No.S3147 Synonyms: OR-611
Molecular Weight(MW): 305.29
Entacapone inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM.
Purity & Quality Control
Choose Selective Histone Methyltransferase Inhibitors
|Description||Entacapone inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM.|
Entacapone inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues.  Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells. 
|In vitro||DMSO||61 mg/mL (199.81 mM)|
|Ethanol||2 mg/mL (6.55 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02554734||Completed||Parkinson''s Disease||Orion Corporation Orion Pharma||August 2015||Phase 1|
|NCT02349243||Unknown status||Obesity||Kaichun Wu|National Institute of Biological Sciences Beijing|Fourth Military Medical University||January 2015||Phase 1|Phase 2|
|NCT01468012||Completed||Cocaine Dependence||New York State Psychiatric Institute||July 2014||Phase 2|Phase 3|
|NCT02058966||Completed||Methamphetamine Dependence||Oregon Health and Science University|Portland VA Medical Center||June 2014||Early Phase 1|
|NCT01840423||Completed||Healthy||Orion Corporation Orion Pharma||May 2013||Phase 1|
|NCT01688089||Completed||Healthy||Orion Corporation Orion Pharma||September 2012||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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